Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
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Stefanetti, Zacharewicz, Della Gatta, Garnham, Russell, Lamon: "Ageing has no effect on the regulation of the ubiquitin proteasome-related genes and proteins following resistance exercise." dans: Frontiers in physiology, Vol. 5, pp. 30, (2014) (PubMed).
Ye, Zhang, Xu, Zhang, Zhu: "FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy." dans: Gene, Vol. 404, Issue 1-2, pp. 53-60, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à FBXO40
F-box protein 40 (Fbxo40), F-box protein 40 (FBXO40), F-box protein 40 (fbxo40), 9830003A13Rik, FBX40, FBXO40, mKIAA1195