FBXW7 Produits
(F-Box and WD Repeat Domain Containing 7 (FBXW7))
Catégories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
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Catégories FBXW7 en vedette
FBXW7 Anticorps
High quality antibodies with extensive validation data.
FBXW7 Kits ELISA
Reliable ELISA kits for a wide range of species.
FBXW7 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FBXW7 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (1)
- (7)
N° du produit
ABIN2782955
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro)
Validations
- (2)
- (3)
N° du produit
ABIN1386103
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (5)
- (3)
N° du produit
ABIN527479
Quantité
100 μg
Fiche technique
Fiche technique
FBXW7 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN1743138
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Sheep
Analytical Method
Validations
N° du produit
ABIN1774043
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Dog
Analytical Method
Validations
N° du produit
ABIN1769147
Quantité
96 tests
Fiche technique
Fiche technique
FBXW7 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1353879
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1990130
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Insect Cells
Validations
N° du produit
ABIN3136692
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits FBXW7
: "miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors." dans: International journal of oncology, Vol. 50, Issue 2, pp. 356-364, (2016) (PubMed).: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." dans: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).
: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." dans: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).
: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." dans: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, (2015) (PubMed).
: "Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway." dans: International journal of oncology, Vol. 47, Issue 1, pp. 231-43, (2015) (PubMed).
: "Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length." dans: The EMBO journal, Vol. 34, Issue 19, pp. 2424-40, (2015) (PubMed).
: "Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry." dans: Cell death and differentiation, Vol. 22, Issue 11, pp. 1775-84, (2015) (PubMed).
: "FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC." dans: Oncotarget, Vol. 6, Issue 14, pp. 12697-709, (2015) (PubMed).
: "STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7." dans: Cancer cell international, Vol. 15, pp. 111, (2015) (PubMed).
: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." dans: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à FBXW7
F-box and WD repeat domain containing 7 (Fbxw7), F-box and WD repeat domain containing 7 (FBXW7), F-box and WD repeat domain containing 7 (fbxw7), F-box and WD-40 domain protein 7 (Fbxw7), 1110001A17Rik, AGO, cdc4, CDC4, Cdc4, FBW6, FBW7, Fbw7, Fbwd6, FBX30, Fbx30, FBXO30, Fbxo30, FBXW6, Fbxw6, hAgo, hCdc4, SEL-10, SEL10Protein level used designations for FBXW7
- F-box and WD-40 domain protein 7
- F-box/WD repeat-containing protein 7
- F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)
- F-box protein FBW7
- F-box protein FBX30
- F-box protein SEL-10
- archipelago
- homolog of C elegans sel-10
- F-box and WD-40 domain protein 7, archipelago homolog
- F-box and WD-40 domain-containing protein 7
- F-box protein Fbxw6
- F-box-WD40 repeat protein 6
- f-box only protein 30
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