FcRn Anticorps
The neonatal Fc receptor (FnRn) owes its name to being the receptor that transports maternal IgG from mother to lactating neonatal offspring and for being identified first in the intestine of neonatal rats as the receptor responsible for the transport of IgG from the lumen to the circulation. However, FcRn functions are far more universal, and it is virtually ubiquitously expressed.
FcRn is considered a non-classical Fc receptor for IgG (FcγR). It is structurally related to major histocompatibility class I (MHC-I) family and it associates with beta-2-microglobulin (β2m). On the other hand, it does not present antigenic peptides to T cells and. It has also a second interaction partner, albumin, that is not involved in the body’s immune response. FcRn prevents intracellular degradation of IgG and albumin and extends their half-life considerable, making them the two most abundant serum proteins.
Because of its interaction with IgG and albumin, FcRn has become a high-interest therapeutic target. For one, it can be exploited to extend the half-life of therapeutic antibodies and IgG- or albumin-fused proteins. Mutations of amino acids influencing the pH dependency of IgG and albumin binding can be mutated to achieve the desired effect. Binding of IgG to FcRn also offers the possibility to enhance their clearance. Autoantibodies that recognized self-antigens are the cause of certain autoimmune diseases. By engineering competing antibodies that bind tighter to FcRn and effectively block the receptor increase clearance of the disease-causing antibodies. Lastly, the FcRn enhances the transport of therapeutic IgG fc or albumin fusion-protein across mucosal membranes, thus facilitating distribution and improving their absorption.
Antibodies for FcRn Research
antibodies-online offers high quality antibodies for FcRn Research. The clones are suitable for research on autoimmune diseases as well as the development of IgG/HSA carrier therapeutica and have already been utilized in a variety of publications in this area. They are thoroughly characterized, including binding sites, binding kinetics, species cross reactivities and applications. Their binding and block capacities were verified in mouse models and assured via two negative controls.
FcRn Antibody (ADM31)
- Blocks Human Serum Albumin
- Works in FACS, IF, WB
- Recognizes Human FcRn
FcRn Antibody (DVN24)
- Blocks Human & Mouse IgG
- Works in FACS, IF
- Recognizes Human & Mouse FcRn
Anti-FcRn antibodies are essential tools to elucidate the biological function of FcRn under normal circumstances and in pathologies such as autoimmune disease and cancer. They enable FcRn imaging in tissue using IHC or IF and quantitation through FACS. As blocking reagents they are useful to identify epitopes on FcRn targeted by antibody-based drugs or albumin-conjugated therapeutics. They can also use autoantibody recycling and influence the half-life of therapeutic antibodies.
Albumin and IgG Binding to the FcRn Heterodimer
FcRn Reactivité: Humain ELISA, IF, FACS, cELISA, Func Hôte: Souris Monoclonal ADM31 unconjugated
FcRn Reactivité: Humain ELISA, IF, FACS, cELISA Hôte: Souris Monoclonal DVN24 unconjugated
FcRn Reactivité: Humain ELISA, IF, FACS, cELISA Hôte: Souris Monoclonal DVN24 unconjugated
FcRn Anticorps par Réactivité
Trouvez FcRn Anticorps pour une variété d'espèces telles que anti-Human FcRn, anti-Cynomolgus FcRn, anti-Mouse FcRn. Les espèces listées ci-dessous sont parmi celles disponibles. Cliquez sur un lien pour accéder aux produits correspondants.
FcRn Anticorps par Hote
On trouve ici des FcRn Anticorps avec un Hote spécifique. Les Hote mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits
FcRn Anticorps par Epitope
Trouver FcRn Anticorps avec un épitope spécifique. Les épitopes listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.
FcRn Anticorps par Clonalité
Trouvez les FcRn Anticorps monoclonaux ou polyclonaux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.
FcRn Anticorps par Clone
On trouve ici des FcRn Anticorps avec un Clone spécifique. Les Clone mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits
FcRn Anticorps par Conjugué
Trouvez FcRn Anticorps avec un conjugué spécifique tel que Biotin, FITC, HRP. Les conjugués listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.
FcRn Anticorps fréquemment utilisés
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Dernières publications pour nos FcRn Anticorps
: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." dans: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).: "Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life." dans: Communications biology, Vol. 5, Issue 1, pp. 832, (2022) (PubMed).
: "FcRn augments induction of tissue factor activity by IgG-containing immune complexes." dans: Blood, Vol. 135, Issue 23, pp. 2085-2093, (2021) (PubMed).
: "FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity." dans: The Journal of experimental medicine, Vol. 217, Issue 10, (2021) (PubMed).
: "An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. ..." dans: Science translational medicine, Vol. 12, Issue 565, (2021) (PubMed).
: "Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis." dans: Science translational medicine, Vol. 12, Issue 566, (2021) (PubMed).
: "Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey." dans: Birth defects research, Vol. 112, Issue 1, pp. 105-117, (2020) (PubMed).
: "Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses. ..." dans: Science advances, Vol. 5, Issue 12, pp. eaax9586, (2020) (PubMed).
: "FcRn-Dependent Transcytosis of Monoclonal Antibody in Human Nasal Epithelial Cells In Vitro: A Prerequisite for a New Delivery Route for Therapy?" dans: International journal of molecular sciences, Vol. 20, Issue 6, (2019) (PubMed).
: "An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans." dans: mAbs, Vol. 11, Issue 5, pp. 942-955, (2019) (PubMed).
Pseudonymes pour FcRn Anticorps
Fc fragment of IgG receptor and transporter (FCGRT) AnticorpsFc fragment of IgG receptor and transporter (Fcgrt) Anticorps
Fc receptor, IgG, alpha chain transporter (Fcgrt) Anticorps
alpha-chain Anticorps
FCRN Anticorps
FcRn Anticorps
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