FEN1 Produits
(Flap Structure-Specific Endonuclease 1 (FEN1))
Catégories
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Catégories FEN1 en vedette
FEN1 Anticorps
High quality antibodies with extensive validation data.
FEN1 Kits ELISA
Reliable ELISA kits for a wide range of species.
FEN1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FEN1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IP, IHC (p), ICC, PLA
Validations
- (6)
N° du produit
ABIN2855166
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (6)
N° du produit
ABIN3021632
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN7255764
Quantité
200 μL
Fiche technique
Fiche technique
FEN1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955927
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1133432
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6217033
Quantité
96 tests
Fiche technique
Fiche technique
FEN1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1353954
Quantité
2 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN1096675
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7424602
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits FEN1
: "Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response." dans: International journal of biological sciences, Vol. 12, Issue 4, pp. 466-77, (2016) (PubMed).: "Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication." dans: The Journal of biological chemistry, Vol. 287, Issue 26, pp. 21980-91, (2012) (PubMed).
: "Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function." dans: Neoplasia (New York, N.Y.), Vol. 14, Issue 6, pp. 495-508, (2012) (PubMed).
: "Prostate cancer cell lines under hypoxia exhibit greater stem-like properties." dans: PLoS ONE, Vol. 6, Issue 12, pp. e29170, (2012) (PubMed).
: "Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair." dans: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 31975-83, (2011) (PubMed).
: "Assembly of the base excision repair complex on abasic DNA and role of adenomatous polyposis coli on its functional activity." dans: Biochemistry, Vol. 50, Issue 11, pp. 1901-9, (2011) (PubMed).
: "DNA polymerase beta-dependent long patch base excision repair in living cells." dans: DNA repair, Vol. 9, Issue 2, pp. 109-19, (2010) (PubMed).
: "FEN1 ensures telomere stability by facilitating replication fork re-initiation." dans: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27057-66, (2010) (PubMed).
: "Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding." dans: Nature chemical biology, Vol. 6, Issue 10, pp. 766-73, (2010) (PubMed).
: "Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance." dans: The Journal of biological chemistry, Vol. 284, Issue 6, pp. 3682-90, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à FEN1
flap structure-specific endonuclease 1 (FEN1), flap endonuclease 1-like (LOC100808044), Flap endonuclease-1 (Bm1_49605), 5'-3' exonuclease family protein (AT5G26680), flap structure specific endonuclease 1 (Fen1), flap structure-specific endonuclease 1 (fen1), flap structure-specific endonuclease 1 L homeolog (fen1.L), flap structure-specific endonuclease 1 (Fen1), nuclease, Rad2 family (FEN1), AW538437, cb879, FEN-1, fen-1, FEN1, fen1, MF1, mf1, RAD2, rad2, xFEN1aProtein level used designations for FEN1
- flap endonuclease 1
- Flap structure-specific endonuclease 1
- flap structure-specific endonuclease 1
- DNase IV
- maturation factor 1
- maturation factor-1
- 5' nuclease xFEN1a
- FEN-1-A
- flap endonuclease 1-A
- flap structure-specific endonuclease 1-A
- xFEN-1a
- FEN-1
Vous êtes ici:
