FMO3 Produits
(Flavin Containing Monooxygenase 3 (FMO3))
Catégories
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009].
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Catégories FMO3 en vedette
FMO3 Anticorps
High quality antibodies with extensive validation data.
FMO3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FMO3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (5)
N° du produit
ABIN7267216
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (3)
N° du produit
ABIN390888
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
N° du produit
ABIN515768
Quantité
50 μg
Fiche technique
Fiche technique
FMO3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354250
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7423360
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2721250
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits FMO3
: "Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma." dans: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 19, Issue 9, pp. 1213-20, (2006) (PubMed).: "Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 30, Issue 10, pp. 1043-52, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à FMO3
flavin containing monooxygenase 3 (FMO3), flavin containing monooxygenase 3 (fmo3), flavin containing monooxygenase 3 L homeolog (fmo3.L), flavin containing monooxygenase 3 (Fmo3), AW111792, dJ127D3.1, FM03, FMOII, MGC107820, TMAUProtein level used designations for FMO3
- dimethylaniline monooxygenase [N-oxide-forming] 3
- flavin containing monooxygenase 3
- FMO 3
- FMO II
- FMO form 2
- dimethylaniline oxidase 3
- hepatic flavin-containing monooxygenase 3
- hepatic flavin-containing monooxygenase-3
- trimethylamine monooxygenase
- flavin-containing monooxygenase 3
- FMO 1D1
- flavin-containing monooxygenase FMO3
- flavin-containing monooxygenase form 3
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