FXYD5 Produits
(FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
Catégories
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
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Catégories FXYD5 en vedette
FXYD5 Anticorps
High quality antibodies with extensive validation data.
FXYD5 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FXYD5 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Saccharomyces cerevisiae
Application
WB
Validations
- (1)
- (3)
N° du produit
ABIN2780210
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7153251
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
N° du produit
ABIN184712
Quantité
100 μg
Fiche technique
Fiche technique
FXYD5 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN1098542
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2129321
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Yeast
Validations
N° du produit
ABIN1474856
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits FXYD5
: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." dans: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).: "FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L654-64, (2008) (PubMed).
: "Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion." dans: Glycobiology, Vol. 13, Issue 7, pp. 521-7, (2003) (PubMed).
: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à FXYD5
FXYD domain containing ion transport regulator 5 (FXYD5), FXYD domain-containing ion transport regulator 5 (Fxyd5), DYSAD, EF-8, FXYD5, IWU1, KCT1, OIT2, Oit2, PRO6241, RICProtein level used designations for FXYD5
- FXYD domain-containing ion transport regulator 5
- FXYD domain containing ion transport regulator 5
- dysadherin
- keratinocytes associated transmembrane protein 1
- ion channel homolog RIC
- oncoprotein induced transcript 2
- oncoprotein-induced protein 2
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