FZR1 Produits
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Catégories
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
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Catégories FZR1 en vedette
FZR1 Anticorps
High quality antibodies with extensive validation data.
FZR1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FZR1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA
Validations
- (5)
N° du produit
ABIN526652
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (5)
N° du produit
ABIN2784494
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (3)
N° du produit
ABIN1714172
Quantité
100 μL
Fiche technique
Fiche technique
FZR1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1133421
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1133422
Quantité
96 tests
Fiche technique
Fiche technique
FZR1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354595
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354593
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3092674
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits FZR1
: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." dans: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).
: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." dans: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).
: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).
: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." dans: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).
: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." dans: Molecular pain, Vol. 12, (2016) (PubMed).
: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." dans: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à FZR1
fizzy and cell division cycle 20 related 1 (Fzr1), fizzy/cell division cycle 20 related 1 (CDH1-C), fizzy and cell division cycle 20 related 1 (FZR1), fizzy-related protein homolog (LOC100027495), fizzy-related protein homolog (LOC100179951), fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1), fizzy/cell division cycle 20 related 1a (fzr1a), AW108046, CDC20C, CDH1, Cdh1, CDH1-C, FYR, Fyr, FZR, fzr1, FZR2, HCDH, HCDH1, zgc:55450Protein level used designations for FZR1
- fizzy-related protein homolog
- fizzy/cell division cycle 20 related 1 (Drosophila)
- fizzy-related protein FZR
- Fizzy-related protein-like protein
- fizzy/cell division cycle 20 related 1
- CDC20-like 1b
- CDC20-like protein 1
- cdh1/Hct1 homolog
- cell division cycle 20 related 1
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- G Antigen 1
- G Antigen 12B
- G Antigen 12F
- G Antigen 12G
- G Antigen 12H
- G Antigen 12I
- G Antigen 13
- G Antigen 2A
- G Antigen 2C
- G Antigen 2D
- G Antigen 4
- G Antigen 5
- G Antigen 7
- G Kinase Anchoring Protein 1
- G Protein-Coupled Receptor 1
- G Protein-Coupled Receptor 110
- G Protein-Coupled Receptor 115
- G Protein-Coupled Receptor 116
- G Protein-Coupled Receptor 119
- G Protein-Coupled Receptor 12
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