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GABRA4 Produits

(gamma-aminobutyric Acid (GABA) A Receptor, alpha 4 (GABRA4))
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011].

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Catégories GABRA4 en vedette

GABRA4 Anticorps

High quality antibodies with extensive validation data.

GABRA4 Kits ELISA

Reliable ELISA kits for a wide range of species.

GABRA4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GABRA4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
N° du produit ABIN7153483
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
  • (3)
N° du produit ABIN3181674
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN2565552
Quantité 100 μg
Fiche technique Fiche technique

GABRA4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6228561
Quantité 96 tests
Fiche technique Fiche technique

GABRA4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN2565117
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1354651
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7423147
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GABRA4

Mo, Kim, Lee, Sun, Lee, Kim: "Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus." dans: Journal of neurochemistry, Vol. 133, Issue 4, pp. 489-500, (2015) (PubMed).

Bekdash, Harrison: "Downregulation of Gabra4 expression during alcohol withdrawal is mediated by specific microRNAs in cultured mouse cortical neurons." dans: Brain and behavior, Vol. 5, Issue 8, pp. e00355, (2015) (PubMed).

Zhou, Ding, Deel, Ferrick, Emeson, Gallagher: "Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome." dans: Neurobiology of disease, Vol. 73C, pp. 407-417, (2014) (PubMed).

Diaz, Christian, Anderson, McCool: "Chronic ethanol and withdrawal differentially modulate lateral/basolateral amygdala paracapsular and local GABAergic synapses." dans: The Journal of pharmacology and experimental therapeutics, Vol. 337, Issue 1, pp. 162-70, (2011) (PubMed).

Panzanelli, Gunn, Schlatter, Benke, Tyagarajan, Scheiffele, Belelli, Lambert, Rudolph, Fritschy: "Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells." dans: The Journal of physiology, Vol. 589, Issue Pt 20, pp. 4959-80, (2011) (PubMed).

Blednov, Walker, Iyer, Homanics, Harris: "Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol." dans: Addiction biology, Vol. 15, Issue 1, pp. 45-61, (2009) (PubMed).

Peden, Petitjean, Herd, Durakoglugil, Rosahl, Wafford, Homanics, Belelli, Fritschy, Lambert: "Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones." dans: The Journal of physiology, Vol. 586, Issue 4, pp. 965-87, (2008) (PubMed).

Pignataro, Miller, Ma, Midha, Protiva, Herrera, Harrison: "Alcohol regulates gene expression in neurons via activation of heat shock factor 1." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 47, pp. 12957-66, (2007) (PubMed).

Marutha Ravindran, Mehta, Ticku: "Effect of chronic administration of ethanol on the regulation of tyrosine kinase phosphorylation of the GABAA receptor subunits in the rat brain." dans: Neurochemical research, Vol. 32, Issue 7, pp. 1179-87, (2007) (PubMed).

Roberts, Raol, Bandyopadhyay, Lund, Budreck, Passini, Passini, Wolfe, Brooks-Kayal, Russek: "Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 33, pp. 11894-9, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à GABRA4

gamma-aminobutyric acid type A receptor alpha4 subunit (GABRA4), gamma-aminobutyric acid type A receptor alpha4 subunit (Gabra4), gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 (Gabra4), Gabra-4, GABRA4

Protein level used designations for GABRA4

  • gamma-aminobutyric acid (GABA) A receptor, alpha 4
  • gamma-aminobutyric acid A receptor, alpha 4
  • GABA(A) receptor subunit alpha-4
  • gamma-aminobutyric acid receptor subunit alpha-4-like
  • GABA-A receptor alpha-4 subunit
  • gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4
  • gamma-aminobutyric acid receptor subunit alpha-4
  • GABA(A) receptor, alpha 4
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