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G6PC Produits

(Glucose 6-Phosphatase, Catalytic (G6PC))
Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011].

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Catégories G6PC en vedette

G6PC Anticorps

High quality antibodies with extensive validation data.

G6PC Kits ELISA

Reliable ELISA kits for a wide range of species.

G6PC Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

G6PC recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (1)
  • (6)
N° du produit ABIN2781770
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (4)
N° du produit ABIN651417
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB
Validations
  • (3)
  • (3)
N° du produit ABIN2781769
Quantité 100 μL
Fiche technique Fiche technique

G6PC recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956119
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956120
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956121
Quantité 96 tests
Fiche technique Fiche technique

G6PC recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1354607
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7409233
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7399592
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits G6PC

Lu, Wang, Jiang, Zhang, Wang, Sha, Chen, Lei, Liu: "Berberine inhibits gluconeogenesis in spontaneous diabetic rats by regulating the AKT/MAPK/NO/cGMP/PKG signaling pathway." dans: Molecular and cellular biochemistry, (2023) (PubMed).

Chen, Henderson, Petriello, Romano, Gearing, Miao, Schell, Sandoval-Espinola, Tao, Sha, Graham, Crooke, Kleinridders, Balskus, Rey, Morris, Biddinger: "Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction." dans: Cell metabolism, Vol. 30, Issue 6, pp. 1141-1151.e5, (2019) (PubMed).

Wang, Ji, Zhang, Zhao, Yan, Zhang, Shen, Yang, Fang, Tian, Zhu, Gong, Zhang, Wei, Wang, Li, Wan, Xie, She, Wang, Huang, Li: "Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates." dans: Nature medicine, Vol. 23, Issue 4, pp. 439-449, (2017) (PubMed).

Wang, Zhang, Luo, Jiang, Zhang, Guo, Zhao, Zhu, Zhang, Yang, Li: "Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling." dans: Nature communications, Vol. 7, pp. 10592, (2016) (PubMed).

Tao, Zhang, Zeng, Shulman, Jin: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." dans: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).

Cicerchi, Li, Kratzer, Garcia, Roncal-Jimenez, Tanabe, Hunter, Rivard, Sautin, Gaucher, Johnson, Lanaspa: "Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 8, pp. 3339-50, (2014) (PubMed).

Yao, Zhuang, Du, Cheng, Yang, Guan, Hu, Zhu, Christine, Shi, Hua: "Role of Fas-associated death domain-containing protein (FADD) phosphorylation in regulating glucose homeostasis: from proteomic discovery to physiological validation." dans: Molecular & cellular proteomics : MCP, Vol. 12, Issue 10, pp. 2689-700, (2013) (PubMed).

Iwasa, Kobayashi, Mifuji-Moroka, Hara, Miyachi, Sugimoto, Tanaka, Fujita, Gabazza, Takei: "Branched-chain amino acid supplementation reduces oxidative stress and prolongs survival in rats with advanced liver cirrhosis." dans: PLoS ONE, Vol. 8, Issue 7, pp. e70309, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à G6PC

glucose-6-phosphatase, catalytic (G6pc), glucose-6-phosphatase catalytic subunit (G6PC), glucose-6-phosphatase, catalytic subunit (G6pc), AW107337, G-6-Pase, G6Pase, G6PC1, G6pt, G6PT, Glc-6-Pase, GSD1, GSD1a

Protein level used designations for G6PC

  • G-6-Pase
  • Glc-6-Pase-alpha
  • glucose-6-phosphatase
  • G6Pase
  • G6Pase-alpha
  • glucose-6-phosphatase alpha
  • glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease)
  • glucose-6-phosphatase catalytic subunit
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