GBA Produits
(Glucosidase, Beta, Acid (GBA))
Catégories
This gene encodes a lysosomal membrane protein that cleaves the beta-glucosidic linkage of glycosylceramide, an intermediate in glycolipid metabolism. Mutations in this gene cause Gaucher disease, a lysosomal storage disease characterized by an accumulation of glucocerebrosides. A related pseudogene is approximately 12 kb downstream of this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010].
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Catégories GBA en vedette
GBA Anticorps
High quality antibodies with extensive validation data.
GBA Kits ELISA
Reliable ELISA kits for a wide range of species.
GBA Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GBA recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
- (6)
N° du produit
ABIN561009
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7434968
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (5)
N° du produit
ABIN7074062
Quantité
100 μL
Fiche technique
Fiche technique
GBA recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967044
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6999571
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956132
Quantité
96 tests
Fiche technique
Fiche technique
GBA recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123107
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354865
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354861
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GBA
: "LRRK2 modifies α-syn pathology and spread in mouse models and human neurons." dans: Acta neuropathologica, Vol. 137, Issue 6, pp. 961-980, (2019) (PubMed).: "Fetal gene therapy for neurodegenerative disease of infants." dans: Nature medicine, Vol. 24, Issue 9, pp. 1317-1323, (2018) (PubMed).
: "Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling." dans: Human molecular genetics, Vol. 24, Issue 5, pp. 1280-94, (2015) (PubMed).
: "Reduced glucocerebrosidase is associated with increased ?-synuclein in sporadic Parkinson's disease." dans: Brain : a journal of neurology, Vol. 137, Issue Pt 3, pp. 834-48, (2014) (PubMed).
: "Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS." dans: Orphanet journal of rare diseases, Vol. 9, pp. 86, (2014) (PubMed).
: "Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease." dans: Kidney international, Vol. 86, Issue 1, pp. 58-66, (2014) (PubMed).
: "Gaucher disease paradigm: from ERAD to comorbidity." dans: Human mutation, Vol. 33, Issue 10, pp. 1398-407, (2012) (PubMed).
: "Characterization of the ERAD process of the L444P mutant glucocerebrosidase variant." dans: Blood cells, molecules & diseases, Vol. 46, Issue 1, pp. 4-10, (2011) (PubMed).
: "Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome." dans: Blood, Vol. 114, Issue 15, pp. 3181-90, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à GBA
glucosylceramidase beta (GBA), beta glucosidase 25 (BGLU25), beta-glucosidase (PSPTO_3318), beta-glucosidase (bglX), Beta-glucosidase (bglA4), glucosidase, beta, acid (Gba), glucosylceramidase beta (Gba), glucosylceramidase (LOC100399524), beta-glucosidase (bglA.2), bglX-2 (bglX-2), glucosidase, beta, acid (GBA), BETA-GLUCOSIDASE, betaGC, beta glucosidase 25, GBA1, GC, GCase, GCB, GLUC, PSPTO3318, PSPTO4290, T12J13.8, T12J13_8Protein level used designations for GBA
- D-glucosyl-N-acylsphingosine glucohydrolase
- acid beta-glucosidase
- alglucerase
- beta-glucocerebrosidase
- glucosylceramidase
- imiglucerase
- lysosomal glucocerebrosidase
- beta-glucosidase
- Beta-glucosidase
- acid beta glucosidase
- glucocerebrosidase
- glucosidase, beta; acid
- glucosidase, beta, acid
- glucosylceramidase-like
- glucosidase, beta; acid (includes glucosylceramidase)
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