This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008].
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Tomilov, Bettaieb, Kim, Sahdeo, Tomilova, Lam, Hagopian, Connell, Fong, Rowland, Griffey, Ramsey, Haj, Cortopassi: "Shc depletion stimulates brown fat activity in vivo and in vitro." dans: Aging cell, Vol. 13, Issue 6, pp. 1049-58, (2014) (PubMed).
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Synonymes et noms alternatifs relatifs à GCKR
glucokinase regulator (GCKR), glucokinase regulator (Gckr), glucokinase regulatory protein (Gckr), glucokinase regulator L homeolog (gckr.L), FGQTL5, gckr, GKRP, GLRE
Protein level used designations for GCKR
glucokinase regulatory protein
glucokinase regulator
LOW QUALITY PROTEIN: glucokinase regulatory protein