GCLM Produits
(Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))
Catégories
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008].
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Catégories GCLM en vedette
GCLM Anticorps
High quality antibodies with extensive validation data.
GCLM Kits ELISA
Reliable ELISA kits for a wide range of species.
GCLM Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GCLM recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (1)
- (7)
N° du produit
ABIN653046
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (11)
N° du produit
ABIN7433051
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (4)
N° du produit
ABIN7154002
Quantité
100 μg
Fiche technique
Fiche technique
GCLM recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967070
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967069
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956169
Quantité
96 tests
Fiche technique
Fiche technique
GCLM recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1354926
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7411648
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7411642
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GCLM
: "A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity." dans: Cell reports, Vol. 26, Issue 6, pp. 1544-1556.e8, (2019) (PubMed).: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." dans: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).
: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).
: "Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 33, pp. E4600-9, (2015) (PubMed).
: "Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice." dans: Free radical biology & medicine, Vol. 68, pp. 148-58, (2014) (PubMed).
: "The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis." dans: Biological trace element research, Vol. 155, Issue 1, pp. 119-31, (2014) (PubMed).
: "Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." dans: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).
: "Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells." dans: Stem cells (Dayton, Ohio), Vol. 29, Issue 4, pp. 600-8, (2011) (PubMed).
: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." dans: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).
: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à GCLM
glutamate-cysteine ligase regulatory subunit (PTRG_09814), glutamate cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (GCLM), glutamate-cysteine ligase, modifier subunit (gclm), glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L), glutamate-cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (Gclm), AI649393, Gcmc, Glclr, GLCLR, id:ibd3182, wu:fi24c07, zgc:55903Protein level used designations for GCLM
- glutamate-cysteine ligase regulatory subunit
- GCS light chain
- gamma-ECS regulatory subunit
- gamma-glutamylcysteine synthetase regulatory subunit
- glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
- glutamate--cysteine ligase regulatory subunit
- glutamate-cysteine ligase modifier subunit
- GSC light chain
- glutamate--cysteine ligase modifier subunit
- glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
- glutamate-cysteine ligase modifier subunit delta2 alternative splicing
- glutamate-cysteine ligase regulatory protein
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