Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

GCLM Produits

(Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Catégories

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq, Jul 2008].

antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.

Catégories GCLM en vedette

GCLM Anticorps

High quality antibodies with extensive validation data.

GCLM Kits ELISA

Reliable ELISA kits for a wide range of species.

GCLM Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GCLM recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, IF, FACS, IHC (p)
Validations
  • (1)
  • (7)
N° du produit ABIN653046
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (11)
N° du produit ABIN7433051
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (4)
N° du produit ABIN7154002
Quantité 100 μg
Fiche technique Fiche technique

GCLM recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967070
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967069
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956169
Quantité 96 tests
Fiche technique Fiche technique

GCLM recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1354926
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7411648
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7411642
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GCLM

Cao, Poddar, Magtanong, Lumb, Mileur, Reid, Dovey, Wang, Locasale, Stone, Cole, Carette, Dixon: "A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity." dans: Cell reports, Vol. 26, Issue 6, pp. 1544-1556.e8, (2019) (PubMed).

Zou, Wang, Peng, Wei: "Oregano Essential Oil Induces SOD1 and GSH Expression through Nrf2 Activation and Alleviates Hydrogen Peroxide-Induced Oxidative Damage in IPEC-J2 Cells." dans: Oxidative medicine and cellular longevity, Vol. 2016, pp. 5987183, (2017) (PubMed).

Li, Sun, Liu, Zhao, Shao: "Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells." dans: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 102, pp. 93-101, (2017) (PubMed).

Lu, Samanta, Xiang, Zhang, Hu, Chen, Bullen, Semenza: "Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 33, pp. E4600-9, (2015) (PubMed).

Tomasi, Ryoo, Yang, Iglesias Ara, Ko, Lu: "Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice." dans: Free radical biology & medicine, Vol. 68, pp. 148-58, (2014) (PubMed).

Chen, Jiang, Hu, Zhang: "The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis." dans: Biological trace element research, Vol. 155, Issue 1, pp. 119-31, (2014) (PubMed).

Ramani, Tomasi, Yang, Ko, Lu: "Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis." dans: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36341-55, (2012) (PubMed).

Sharon, Mor, Golan-lev, Fainsod, Benvenisty: "Molecular and functional characterizations of gastrula organizer cells derived from human embryonic stem cells." dans: Stem cells (Dayton, Ohio), Vol. 29, Issue 4, pp. 600-8, (2011) (PubMed).

Abel, Bubel, Simper, Powell, McClellan, Andreeff, MacLeod, DiGiovanni: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." dans: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).

Hardwick, Fisher, Canet, Lake, Cherrington: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).

Synonymes et noms alternatifs relatifs à GCLM

glutamate-cysteine ligase regulatory subunit (PTRG_09814), glutamate cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (GCLM), glutamate-cysteine ligase, modifier subunit (gclm), glutamate-cysteine ligase, modifier subunit L homeolog (gclm.L), glutamate-cysteine ligase, modifier subunit (Gclm), glutamate-cysteine ligase modifier subunit (Gclm), AI649393, Gcmc, Glclr, GLCLR, id:ibd3182, wu:fi24c07, zgc:55903

Protein level used designations for GCLM

  • glutamate-cysteine ligase regulatory subunit
  • GCS light chain
  • gamma-ECS regulatory subunit
  • gamma-glutamylcysteine synthetase regulatory subunit
  • glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory
  • glutamate--cysteine ligase regulatory subunit
  • glutamate-cysteine ligase modifier subunit
  • GSC light chain
  • glutamate--cysteine ligase modifier subunit
  • glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)
  • glutamate-cysteine ligase modifier subunit delta2 alternative splicing
  • glutamate-cysteine ligase regulatory protein
Vous êtes ici:
Support technique