Geminin Produits
(Geminin, DNA Replication Inhibitor (GMNN))
Catégories
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
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Catégories Geminin en vedette
Geminin Anticorps
High quality antibodies with extensive validation data.
Geminin Kits ELISA
Reliable ELISA kits for a wide range of species.
Geminin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Geminin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (7)
N° du produit
ABIN565518
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN6141186
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (1)
- (2)
N° du produit
ABIN1574066
Quantité
40 μg
Fiche technique
Fiche technique
Geminin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1134607
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1134608
Quantité
96 tests
Fiche technique
Fiche technique
Geminin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1355304
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1355302
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN667697
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Geminin
: "GEMC1 is a critical regulator of multiciliated cell differentiation." dans: The EMBO journal, Vol. 35, Issue 9, pp. 942-60, (2016) (PubMed).: "Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors." dans: Development (Cambridge, England), Vol. 142, Issue 1, pp. 70-81, (2014) (PubMed).
: "Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis." dans: Nature communications, Vol. 4, pp. 1885, (2013) (PubMed).
: "Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex." dans: Nature cell biology, Vol. 15, Issue 7, pp. 797-806, (2013) (PubMed).
: "Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation." dans: Molecular and cellular biology, Vol. 29, Issue 10, pp. 2609-21, (2009) (PubMed).
: "The regulation of embryonic patterning and DNA replication by geminin." dans: Cellular and molecular life sciences : CMLS, Vol. 62, Issue 13, pp. 1425-33, (2005) (PubMed).
: "The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions." dans: Nature, Vol. 427, Issue 6976, pp. 749-53, (2004) (PubMed).
: "Increased expression of geminin stimulates the growth of mammary epithelial cells and is a frequent event in human tumors." dans: Journal of cellular physiology, Vol. 202, Issue 1, pp. 215-22, (2004) (PubMed).
: "Identification of BRCA1-IRIS, a BRCA1 locus product." dans: Nature cell biology, Vol. 6, Issue 10, pp. 954-67, (2004) (PubMed).
: "DNA replication licensing in somatic and germ cells." dans: Journal of cell science, Vol. 117, Issue Pt 24, pp. 5875-86, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à Geminin
geminin, DNA replication inhibitor (GMNN), CG3183 gene product from transcript CG3183-RA (geminin), geminin, DNA replication inhibitor (gmnn), geminin (LOC410093), GE24654 gene product from transcript GE24654-RA (Dyak\geminin), geminin (Gmnn), geminin, DNA replication inhibitor (Gmnn), anon-WO0257455.1, AW546347, CG3183, Dmel\\CG3183, Dm Geminin, Dm geminin, DyakGE24654, dyak_GLEANR_833, GB16871, GE24654, Gem, gem, Geminin, geminin, GMNN, l(2)k14019, LOC100049517, sb:cb254, v(2)k09107, zgc:66217Protein level used designations for Geminin
- CG3183-PA
- CG3183-PB
- geminin-PA
- geminin-PB
- geminin
- geminin protein
- geminin, DNA replication inhibitor
- DyakGE24654-PA
- Dyakgeminin-PA
- GE24654-PA
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