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GFI1 Produits

(Growth Factor Independent 1 (GFI1))

Catégories

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

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Catégories GFI1 en vedette

GFI1 Anticorps

High quality antibodies with extensive validation data.

GFI1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GFI1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (5)
N° du produit ABIN561035
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7245050
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA
Validations
  • (2)
  • (1)
N° du produit ABIN969174
Quantité 100 μL
Fiche technique Fiche technique

GFI1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6222660
Quantité 96 tests
Fiche technique Fiche technique

GFI1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355013
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3092738
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3134645
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits GFI1

Duran Alonso, Lopez Hernandez, de la Fuente, Garcia-Sancho, Giraldez, Schimmang: "Transcription factor induced conversion of human fibroblasts towards the hair cell lineage." dans: PLoS ONE, Vol. 13, Issue 7, pp. e0200210, (2019) (PubMed).

Vadnais, Chen, Fraszczak, Yu, Boulais, Pinder, Frank, Khandanpour, Hébert, Dellaire, Côté, Richard, Orthwein, Drobetsky, Möröy: "GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1." dans: Nature communications, Vol. 9, Issue 1, pp. 1418, (2018) (PubMed).

Olsson, Venkatasubramanian, Chaudhri, Aronow, Salomonis, Singh, Grimes: "Single-cell analysis of mixed-lineage states leading to a binary cell fate choice." dans: Nature, Vol. 537, Issue 7622, pp. 698-702, (2017) (PubMed).

Fraszczak, Helness, Chen, Vadnais, Robert, Khandanpour, Möröy: "Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1." dans: PLoS ONE, Vol. 11, Issue 7, pp. e0160344, (2017) (PubMed).

Northcott, Lee, Zichner, Stütz, Erkek, Kawauchi, Shih, Hovestadt, Zapatka, Sturm, Jones, Kool, Remke, Cavalli, Zuyderduyn, Bader, VandenBerg, Esparza, Ryzhova, Wang, Wittmann, Stark, Sieber et al.: "Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma. ..." dans: Nature, Vol. 511, Issue 7510, pp. 428-34, (2014) (PubMed).

Dwivedi, Anderson, Tilley, May, Morris: "Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells." dans: The Journal of steroid biochemistry and molecular biology, Vol. 103, Issue 3-5, pp. 742-6, (2007) (PubMed).

Kimura, Wakamatsu, Suzuki, Ota, Nishikawa, Yamashita, Yamamoto, Sekine, Tsuritani, Wakaguri, Ishii, Sugiyama, Saito, Isono, Irie, Kushida, Yoneyama, Otsuka, Kanda, Yokoi, Kondo, Wagatsuma, Murakawa et al.: "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. ..." dans: Genome research, Vol. 16, Issue 1, pp. 55-65, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à GFI1

growth factor independent 1 (Gfi1), growth factor independent 1 transcriptional repressor (GFI1), growth factor independent 1 transcriptional repressor (Gfi1), AW495828, Gfi-1, GFI-1, GFI1, GFI1A, Pal-1, Pal1, SCN2, ZNF163

Protein level used designations for GFI1

  • growth factor independent protein 1
  • zinc finger protein Gfi-1
  • growth factor independent 1
  • Growth factor independent-1
  • growth factor independence-1
  • zinc finger protein 163
  • growth factor independence 1
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