Granulin Produits
(Granulin (GRN))
Catégories
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
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Catégories Granulin en vedette
Granulin Anticorps
High quality antibodies with extensive validation data.
Granulin Kits ELISA
Reliable ELISA kits for a wide range of species.
Granulin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Granulin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7440077
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7440863
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ICC, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN2854868
Quantité
100 μL
Fiche technique
Fiche technique
Granulin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
N° du produit
ABIN6730966
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
N° du produit
ABIN6967189
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956290
Quantité
96 tests
Fiche technique
Fiche technique
Granulin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (3)
- (1)
N° du produit
ABIN1355792
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123193
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123192
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Granulin
: "GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium - potential biomarkers in the detection of endometriosis - a pilot study." dans: Journal of assisted reproduction and genetics, Vol. 37, Issue 11, pp. 2723-2732, (2020) (PubMed).: "The effects of serum granulin levels on anthropometric measures and glucose metabolism in infertile women with different ovarian reserve status." dans: Endokrynologia Polska, Vol. 70, Issue 3, pp. 255-259, (2019) (PubMed).
: "Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Issue 12, pp. E2849-E2858, (2018) (PubMed).
: "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations." dans: eNeuro, Vol. 4, Issue 4, (2018) (PubMed).
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." dans: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." dans: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness." dans: Oncogene, Vol. 34, Issue 14, pp. 1853-64, (2015) (PubMed).
: "The molecular basis for development of proinflammatory autoantibodies to progranulin." dans: Journal of autoimmunity, Vol. 61, pp. 17-28, (2015) (PubMed).
: "Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment." dans: Journal of neuroinflammation, Vol. 12, pp. 200, (2015) (PubMed).
: "Associations between longer habitual day napping and non-alcoholic fatty liver disease in an elderly Chinese population." dans: PLoS ONE, Vol. 9, Issue 8, pp. e105583, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à Granulin
granulin precursor (GRN), granulin a (grna), Granulins (grn), granulin L homeolog (grn.L), granulin (granulin), granulin (ORF1 granulin), granulin precursor (Grn), granulin (Grn), acrogranin, CLN11, DKFZp459H066, epithelin, GEP, GP88, GRN, grn, MGC53354, PCDGF, PEPI, PGRN, wu:fb11g12, wu:fj18f05Protein level used designations for Granulin
- granulin
- granulin-a
- zfPGRN-A
- Granulins
- PC cell-derived growth factor
- acrogranin
- granulin-epithelin
- granulins
- proepithelin
- progranulin
- PCDGF
- PEPI
- acrogranulin
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