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GRB10 Produits

(Growth Factor Receptor-Bound Protein 10 (GRB10))

Catégories

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].

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Catégories GRB10 en vedette

GRB10 Anticorps

High quality antibodies with extensive validation data.

GRB10 Kits ELISA

Reliable ELISA kits for a wide range of species.

GRB10 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GRB10 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (7)
N° du produit ABIN7436048
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN561124
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN3184930
Quantité 100 μL
Fiche technique Fiche technique

GRB10 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967246
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956335
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380446
Quantité 2 x 96 tests
Fiche technique Fiche technique

GRB10 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355698
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355696
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7398446
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GRB10

Nantel, Mohammad-Ali, Sherk, Posner, Thomas: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." dans: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).

Frantz, Giorgetti-Peraldi, Ottinger, Shoelson: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." dans: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).

Dong, Du, Porter, Kolakowski, Lee, Mandarino, Fan, Yee, Liu, Mandarino: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." dans: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).

ONeill, Rose, Pillay, Hotta, Olefsky, Gustafson: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." dans: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).

Liu, Roth: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).

Synonymes et noms alternatifs relatifs à GRB10

growth factor receptor bound protein 10 (GRB10), growth factor receptor-bound protein 10a (grb10a), growth factor receptor bound protein 10 (grb10), growth factor receptor bound protein 10 L homeolog (grb10.L), growth factor receptor-bound protein 10 (LOC100434903), growth factor receptor bound protein 10 (Grb10), 5730571D09Rik, AI325020, grb-10, Grb-10, grb-ir, GRB-IR, grb10, GRB10, irbp, IRBP, LOC100224775, meg1, Meg1, MEG1, mKIAA0207, RGD1566234, rss, RSS, zgc:91987

Protein level used designations for GRB10

  • growth factor receptor-bound protein 10
  • zgc:91987growth factor receptor-bound protein 10
  • growth factor receptor-bound protein 10-like
  • GRB10 adapter protein
  • maternally expressed gene 1 protein
  • GRB10 adaptor protein
  • insulin receptor-binding protein Grb-IR
  • maternally expressed gene 1
  • adapter protein
  • binds to insulin receptor and IGF1R
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