GRB10 Produits
(Growth Factor Receptor-Bound Protein 10 (GRB10))
Catégories
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010].
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Catégories GRB10 en vedette
GRB10 Anticorps
High quality antibodies with extensive validation data.
GRB10 Kits ELISA
Reliable ELISA kits for a wide range of species.
GRB10 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GRB10 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
- (7)
N° du produit
ABIN7436048
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN561124
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN3184930
Quantité
100 μL
Fiche technique
Fiche technique
GRB10 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967246
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956335
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380446
Quantité
2 x 96 tests
Fiche technique
Fiche technique
GRB10 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1355698
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1355696
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7398446
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GRB10
: "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases." dans: The Journal of biological chemistry, Vol. 273, Issue 17, pp. 10475-84, (1998) (PubMed).: "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains." dans: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2659-67, (1997) (PubMed).
: "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma." dans: The Journal of biological chemistry, Vol. 272, Issue 46, pp. 29104-12, (1997) (PubMed).
: "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling." dans: The Journal of biological chemistry, Vol. 271, Issue 37, pp. 22506-13, (1996) (PubMed).
: "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 22, pp. 10287-91, (1995) (PubMed).
Synonymes et noms alternatifs relatifs à GRB10
growth factor receptor bound protein 10 (GRB10), growth factor receptor-bound protein 10a (grb10a), growth factor receptor bound protein 10 (grb10), growth factor receptor bound protein 10 L homeolog (grb10.L), growth factor receptor-bound protein 10 (LOC100434903), growth factor receptor bound protein 10 (Grb10), 5730571D09Rik, AI325020, grb-10, Grb-10, grb-ir, GRB-IR, grb10, GRB10, irbp, IRBP, LOC100224775, meg1, Meg1, MEG1, mKIAA0207, RGD1566234, rss, RSS, zgc:91987Protein level used designations for GRB10
- growth factor receptor-bound protein 10
- zgc:91987growth factor receptor-bound protein 10
- growth factor receptor-bound protein 10-like
- GRB10 adapter protein
- maternally expressed gene 1 protein
- GRB10 adaptor protein
- insulin receptor-binding protein Grb-IR
- maternally expressed gene 1
- adapter protein
- binds to insulin receptor and IGF1R
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