GREM1 Produits
(Gremlin 1 (GREM1))
Catégories
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
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Catégories GREM1 en vedette
GREM1 Anticorps
High quality antibodies with extensive validation data.
GREM1 Kits ELISA
Reliable ELISA kits for a wide range of species.
GREM1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
GREM1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB
Validations
- (9)
- (7)
N° du produit
ABIN390078
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (5)
N° du produit
ABIN687082
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7434692
Quantité
100 μL
Fiche technique
Fiche technique
GREM1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (9)
- (6)
N° du produit
ABIN6730963
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6962271
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967209
Quantité
96 tests
Fiche technique
Fiche technique
GREM1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
- (5)
N° du produit
ABIN6119725
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (2)
N° du produit
ABIN4949105
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123201
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits GREM1
: "Gremlin in the Vitreous of Patients with Proliferative Diabetic Retinopathy and the Downregulation of Gremlin in Retinal Pigment Epithelial Cells." dans: Journal of diabetes research, Vol. 2020, pp. 9238742, (2021) (PubMed).: "Gremlin, A Potential Urinary Biomarker of Anca-Associated Crescentic Glomerulonephritis." dans: Scientific reports, Vol. 9, Issue 1, pp. 6867, (2020) (PubMed).
: "Gremlin-1 activates Akt/STAT3 signaling, which increases the glycolysis rate in breast cancer cells." dans: Biochemical and biophysical research communications, Vol. 533, Issue 4, pp. 1378-1384, (2020) (PubMed).
: "Platelets as a novel source of Gremlin-1: Implications for thromboinflammation." dans: Thrombosis and haemostasis, Vol. 117, Issue 2, pp. 311-324, (2018) (PubMed).
: "The BMP2 variant L51P restores the osteogenic differentiation of human mesenchymal stromal cells in the presence of intervertebral disc cells." dans: European cells & materials, Vol. 33, pp. 197-210, (2017) (PubMed).
: "Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients. ..." dans: Scientific reports, Vol. 7, pp. 44941, (2017) (PubMed).
: "Gremlin-1 suppression increases BMP-2-induced osteogenesis of human mesenchymal stem cells." dans: Molecular medicine reports, Vol. 15, Issue 4, pp. 2186-2194, (2017) (PubMed).
: "Overexpression of Gremlin promotes non-small cell lung cancer progression." dans: Tumour biology, Vol. 37, Issue 2, pp. 2597-602, (2016) (PubMed).
: "GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness." dans: The Journal of rheumatology, Vol. 43, Issue 3, pp. 474-85, (2016) (PubMed).
: "Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension." dans: American journal of respiratory cell and molecular biology, Vol. 55, Issue 4, pp. 564-575, (2016) (PubMed).
Synonymes et noms alternatifs relatifs à GREM1
gremlin 1a, DAN family BMP antagonist (grem1a), gremlin 1, DAN family BMP antagonist (GREM1), gremlin 1 (LOC662541), gremlin 1, DAN family BMP antagonist (grem1), gremlin 1, DAN family BMP antagonist (Grem1), gremlin 1, DAN family BMP antagonist L homeolog (grem1.L), Cktsf1b1, CKTSF1B1, cktsf1b1, dand2, DAND2, drm, Drm, DRM, Grem, grem1, GREM1, gremlin, GREMLIN, gremlin-1, ihg-2, IHG-2, ld, MGC136702, pig2, zgc:136702Protein level used designations for GREM1
- gremlin 1 homolog a, cysteine knot superfamily
- gremlin 1 homolog, cysteine knot superfamily
- gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
- gremlin 1
- GLEAN_07044
- cysteine knot superfamily 1
- cysteine knot superfamily 1, BMP antagonist 1
- down-regulated in Mos-transformed cells protein
- down-regulated in v-mos-transformed cells
- gremlin-1
- gremlin 1, cysteine knot superfamily, homolog
- Cysteine knot superfamily 1, BMP antagonist 1
- DAN domain family member 2
- cell proliferation-inducing gene 2 protein
- gremlin 1-like protein
- increased in high glucose-2
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