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GRK2 Produits

(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008].

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Catégories GRK2 en vedette

GRK2 Anticorps

High quality antibodies with extensive validation data.

GRK2 Kits ELISA

Reliable ELISA kits for a wide range of species.

GRK2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GRK2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC (p), IF, ICC, FACS, IP
Validations
  • (6)
N° du produit ABIN2855125
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (6)
N° du produit ABIN3022346
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IHC, ICC
Validations
  • (2)
  • (4)
N° du produit ABIN969178
Quantité 100 μL
Fiche technique Fiche technique

GRK2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964661
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964660
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6964659
Quantité 96 tests
Fiche technique Fiche technique

GRK2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1344492
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5508944
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
N° du produit ABIN7317491
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits GRK2

Nakano, Onoue, Nakada, Nakagawa, Kumazawa, Ueda, Nishida, Soeda, Okayama, Watanabe, Kawata, Kawakami, Horii, Okura, Uemura, Hatakeyama, Sakaguchi, Saito: "Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study." dans: Scientific reports, Vol. 8, Issue 1, pp. 12731, (2018) (PubMed).

Sterne-Marr, Leahey, Bresee, Dickson, Ho, Ragusa, Donnelly, Amie, Krywy, Brookins-Danz, Orakwue, Carr, Yoshino-Koh, Li, Tesmer: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." dans: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).

Rao, Rapoport, Kim: "Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients." dans: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), Vol. 12, Issue 6, pp. 851-60, (2009) (PubMed).

Chen, Long, Wu, Jiang, Ma: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." dans: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, (2008) (PubMed).

Iaccarino, Barbato, Cipolletta, De Amicis, Margulies, Leosco, Trimarco, Koch: "Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure." dans: European heart journal, Vol. 26, Issue 17, pp. 1752-8, (2005) (PubMed).

Eichmann, Lorenz, Hoffmann, Brockmann, Krasel, Lohse, Quitterer: "The amino-terminal domain of G-protein-coupled receptor kinase 2 is a regulatory Gbeta gamma binding site." dans: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8052-7, (2003) (PubMed).

Li, Xiang, Su, Zhang, Huang, Ma: "Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo." dans: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 30219-26, (2003) (PubMed).

Wan, Sambi, Tate, Waters, Pyne et al.: "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated ..." dans: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18658-63, (2003) (PubMed).

Yang, Zhang, Lai, Xing, Liu: "Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase." dans: World journal of gastroenterology : WJG, Vol. 9, Issue 4, pp. 800-3, (2003) (PubMed).

Hagen, Kondyra, Grocott, El-Moalem, Bainbridge, Mathew, Newman, Reves, Schwinn, Kwatra: "Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells." dans: Anesthesiology, Vol. 98, Issue 2, pp. 343-8, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à GRK2

beta-adrenergic receptor kinase 1 (Tsp_00497), G protein-coupled receptor kinase 2 (grk2), G protein-coupled receptor kinase 2 (Grk2), G protein-coupled receptor kinase 2 (GRK2), Adrbk-1, Bark-1, BARK1, BETA-ARK1, betaARK1, GRK-2, GRK2, Grk2

Protein level used designations for GRK2

  • beta-adrenergic receptor kinase 1
  • adrenergic, beta, receptor kinase 1
  • G-protein-coupled receptor kinase 2
  • beta ARK
  • beta ARK1
  • beta-AR kinase-1
  • beta-ARK-1
  • beta-adrenergic receptor kinase-1
  • G-protein coupled receptor kinase 2
  • adrenergic receptor kinase, beta 1
  • beta-adrenergic receptor kinase 1 beta ARK1
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