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Hairy and Enhancer of Split 4 Produits

(Hairy and Enhancer of Split 4 (HES4))

Catégories

Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Promotes floor plate development and prechordal plate development. Required for lens development as early as the stage of lens field formation, partly through regulation of gene expression of the cell cycle inhibitor cdknx/p27(xic1). Required for formation of the neural crest downstream of multiple signaling pathways, and acts at the neural plate border via both DNA-binding dependent and independent mechanisms. Also acts via repressor- dependent and repressor-independent mechanisms in early gastrulae to establish the prospective anterior prechordal mesoderm identity in the Spemann organizer\; induces specific genes independently from direct transcriptional regulation, and represses the genes specific for neighboring tissues through direct transcriptional repression. Modulates lateral inhibition during notch signaling and regulates the cell context dependent effects of notch (which can have inhibitory, permissive or enhancing roles in muscle or neural differentiation). Inhibits myogenesis (By similarity).

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Catégories Hairy and Enhancer of Split 4 en vedette

Hairy and Enhancer of Split 4 Anticorps

High quality antibodies with extensive validation data.

Hairy and Enhancer of Split 4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Hairy and Enhancer of Split 4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN2565591
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Cow, Human, Monkey
Application WB
Validations
  • (1)
N° du produit ABIN202082
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN202081
Quantité 100 μL
Fiche technique Fiche technique

Hairy and Enhancer of Split 4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306551
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3081428
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN2722664
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Hairy and Enhancer of Split 4

El Yakoubi, Borday, Hamdache, Parain, Tran, Vleminckx, Perron, Locker: "Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis." dans: Stem cells (Dayton, Ohio), Vol. 30, Issue 12, pp. 2784-95, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à Hairy and Enhancer of Split 4

hes family bHLH transcription factor 4 (HES4), hes family bHLH transcription factor 4 (hes4), hes family bHLH transcription factor 4 L homeolog (hes4.L), hes family bHLH transcription factor 4 S homeolog (hes4.S), bHLHb42, hairy2, hairy2a, hairy2b, hes1, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2a, Xhairy2b

Protein level used designations for Hairy and Enhancer of Split 4

  • bHLH factor Hes4
  • class B basic helix-loop-helix protein 42
  • hHES4
  • transcription factor HES-4
  • Protein hairy-2
  • hairy and enhancer of split 1
  • transcription factor HES-4-B
  • hairy2b
  • Protein hairy-2a
  • Hairy and enhancer of split 4-B
  • transcription factor HES-4-A
  • Hairy and enhancer of split 4-A
  • basic-helix-loop-helix transcription factor hairy2
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