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HIRA Produits

(HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Catégories

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008].

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Catégories HIRA en vedette

HIRA Anticorps

High quality antibodies with extensive validation data.

HIRA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

HIRA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (5)
N° du produit ABIN6141776
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (4)
N° du produit ABIN7264499
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, FACS
Validations
  • (4)
N° du produit ABIN1490946
Quantité 100 μL
Fiche technique Fiche technique

HIRA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306658
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1306657
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3092925
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits HIRA

Inoue, Zhang: "Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes." dans: Nature structural & molecular biology, Vol. 21, Issue 7, pp. 609-16, (2014) (PubMed).

Jiang, Nguyen, Cao, Chang, Reddel: "HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a." dans: PLoS ONE, Vol. 6, Issue 2, pp. e17036, (2011) (PubMed).

Zhang, Chen, Adams: "Molecular dissection of formation of senescence-associated heterochromatin foci." dans: Molecular and cellular biology, Vol. 27, Issue 6, pp. 2343-58, (2007) (PubMed).

Tang, Poustovoitov, Zhao, Garfinkel, Canutescu, Dunbrack, Adams, Marmorstein: "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly." dans: Nature structural & molecular biology, Vol. 13, Issue 10, pp. 921-9, (2006) (PubMed).

Yang, Zhang, Kudlow: "Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression." dans: Cell, Vol. 110, Issue 1, pp. 69-80, (2002) (PubMed).

Bone, Roth: "Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation." dans: The Journal of biological chemistry, Vol. 276, Issue 3, pp. 1808-13, (2001) (PubMed).

Watson, Edmondson, Bone, Mukai, Yu, Du, Stillman, Roth: "Ssn6-Tup1 interacts with class I histone deacetylases required for repression." dans: Genes & development, Vol. 14, Issue 21, pp. 2737-44, (2000) (PubMed).

Synonymes et noms alternatifs relatifs à HIRA

histone cell cycle regulator (HIRA), histone cell cycle regulator a (hira), protein HIRA (LOC100052845), protein HIRA (LOC100352472), HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (HIRA), protein HIRA (LOC100407742), protein HIRA (LOC100450459), protein HIRA (LOC100467668), protein HIRA (LOC100581135), protein HIRA (LOC486424), histone cell cycle regulator (Hira), HIRA (LOC732736), histone cell cycle regulator S homeolog (hira.S), histone chaperone HIRA-like protein (HIRA), Tuple1/HirA (hira), AA138857, D16Ertd95e, DGCR1, dgcr1, HIRA, hira-A, homolog of histone chaperone HIRA, N28177, si:ch211-188g24.3, TUP1, tup1, Tuple1, TUPLE1, tuple1, wu:fb97b07, wu:fi43b08

Protein level used designations for HIRA

  • HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
  • fb97b07
  • HIR histone cell cycle regulation defective homolog A-like
  • protein HIRA-like
  • histone cell cycle regulation defective homolog A
  • protein HIRA
  • TUP1-like enhancer of split protein 1
  • cHIRA
  • histone regulator protein
  • TUP1-like enhancer of split gene 1
  • DiGeorge critical region gene 1
  • HIR histone cell cycle regulation defective homolog A
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