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HLA-C Produits

(Major Histocompatibility Complex Class I C (HLA-C))

Catégories

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].

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Catégories HLA-C en vedette

HLA-C Anticorps

High quality antibodies with extensive validation data.

HLA-C Kits ELISA

Reliable ELISA kits for a wide range of species.

HLA-C Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

HLA-C recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (8)
N° du produit ABIN7434662
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (5)
N° du produit ABIN7155625
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (4)
N° du produit ABIN7155571
Quantité 100 μg
Fiche technique Fiche technique

HLA-C recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968422
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962562
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1571212
Quantité 96 tests
Fiche technique Fiche technique

HLA-C recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123828
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN2752815
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN2129739
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits HLA-C

Huang, Malu, McKenzie, Andrews, Talukder, Tieu, Karpinets, Haymaker, Forget, Williams, Wang, Mbofung, Wang, Davis, Lo, Wargo, Davies, Bernatchez, Heffernan, Amaria, Korkut, Peng, Roszik, Lizée et al.: "The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression. ..." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 14, pp. 3366-3376, (2018) (PubMed).

Apps, Qi, Carlson, Chen, Gao, Thomas, Yuki, Del Prete, Goulder, Brumme, Brumme, John, Mallal, Nelson, Bosch, Heckerman, Stein, Soderberg, Moody, Denny, Zeng, Fang, Moffett, Lifson, Goedert et al.: "Influence of HLA-C expression level on HIV control. ..." dans: Science (New York, N.Y.), Vol. 340, Issue 6128, pp. 87-91, (2013) (PubMed).

Corrah, Goonetilleke, Kopycinski, Deeks, Cohen, Borrow, McMichael, Brackenridge: "Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression." dans: Journal of virology, Vol. 85, Issue 7, pp. 3367-74, (2011) (PubMed).

Braud, Allan, Wilson, McMichael: "TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide." dans: Current biology : CB, Vol. 8, Issue 1, pp. 1-10, (1998) (PubMed).

Synonymes et noms alternatifs relatifs à HLA-C

major histocompatibility complex, class I, C (HLA-C), D6S204, HLA-JY3, HLC-C, PSORS1

Protein level used designations for HLA-C

  • HLA class I histocompatibility antigen, C alpha chain
  • HLA class I histocompatibility antigen, Cw-1 alpha chain
  • MHC class I antigen heavy chain HLA-C
  • human leukocyte antigen-C alpha chain
  • major histocompatibility antigen HLA-C
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