HMGCR Produits
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Catégories
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
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Catégories HMGCR en vedette
HMGCR Anticorps
High quality antibodies with extensive validation data.
HMGCR Kits ELISA
Reliable ELISA kits for a wide range of species.
HMGCR Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
HMGCR recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (2)
- (9)
N° du produit
ABIN3022294
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7435559
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (2)
- (3)
N° du produit
ABIN753283
Quantité
100 μL
Fiche technique
Fiche technique
HMGCR recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
N° du produit
ABIN6953355
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964469
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6964468
Quantité
96 tests
Fiche technique
Fiche technique
HMGCR recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7121607
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1306814
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7284949
Quantité
200 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits HMGCR
: "Fluvastatin is effective against thymic carcinoma." dans: Life sciences, Vol. 240, pp. 117110, (2020) (PubMed).: "Transthyretin Regulated by linc00657/miR-205-5p Promoted Cholesterol Metabolism by Inducing SREBP2-HMGCR and Inhibiting LXRα-CYP7A1." dans: Archives of medical research, Vol. 51, Issue 4, pp. 317-326, (2020) (PubMed).
: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." dans: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
: "27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells." dans: Neurotoxicology, Vol. 59, pp. 88-97, (2017) (PubMed).
: "Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism." dans: Journal of agricultural and food chemistry, Vol. 65, Issue 40, pp. 8829-8838, (2017) (PubMed).
: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." dans: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
: "Leoligin, the major lignan from Edelweiss, inhibits 3-hydroxy-3-methyl-glutaryl-CoA reductase and reduces cholesterol levels in ApoE-/- mice." dans: Journal of molecular and cellular cardiology, Vol. 99, pp. 35-46, (2016) (PubMed).
: "Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)." dans: BMC complementary and alternative medicine, Vol. 16, pp. 51, (2016) (PubMed).
: "Effects of SIRT1 gene knock-out via activation of SREBP2 protein-mediated PI3K/AKT signaling on osteoarthritis in mice." dans: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 36, Issue 5, pp. 683-690, (2016) (PubMed).
: "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." dans: Life sciences, Vol. 151, pp. 50-60, (2016) (PubMed).
Synonymes et noms alternatifs relatifs à HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog (hmgcr.L), 3-hydroxy-3-methylglutaryl-Coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-CoA reductase (Hmgcr), HMG Coenzyme A reductase (Hmgcr), 3-hydroxy-3-methylglutaryl-CoA reductase b (hmgcrb), 3H3M, BcDNA:LD15354, bro1, bs32f05.y1, CG10367, Clb, clb, Dmel\\CG10367, DmHMG-CoAr, Hmg, hmg-coa-r, HMG-CoAR, HmG-CoAR, hmgc, HMGCoAR, HMGCoAr, HMGCoARr, HMGCR, hmgcr, hmgcr2, HMGCR_Dm, HMGR, hmgrc, im:6912716, l(3)01152, l(3)04684, LDLCQ3, Red, zgc:110746Protein level used designations for HMGCR
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase/HMG-CoA reductase
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
- HMG-CoA reductase
- hydroxymethylglutaryl-CoA reductase
- 3-hydroxy-3-methylglutaryl CoA reductase
- 3-hydroxy-3-methylglutaryl-CoA reductase
- 3-Hydroxy-3-Methylglutaryl CoA reductase
- 3-hydroxy-3-methylglutaryl coenzyme A reductase
- CG10367-PA
- HMG coenzyme A reductase
- HMGCo-A reductase
- HMGCoA reductase
- Hmg-CoA-reductase
- Hmgcr-PA
- columbus
- lethal (3) 04684
- 3-alpha-hydroxy-3-methylglutaryl-CoA reductase
- 3-hydroxy-3-methylglutaryl-CoA reductase b
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b
- hmgcr1b
- hmgrb
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