HSPG2 Produits
(Heparan Sulfate Proteoglycan 2 (HSPG2))
Catégories
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].
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Catégories HSPG2 en vedette
HSPG2 Anticorps
High quality antibodies with extensive validation data.
HSPG2 Kits ELISA
Reliable ELISA kits for a wide range of species.
HSPG2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
HSPG2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (12)
N° du produit
ABIN7435115
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
N° du produit
ABIN7191019
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
IHC, ELISA
Validations
- (2)
N° du produit
ABIN7243733
Quantité
200 μL
Fiche technique
Fiche technique
HSPG2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (4)
N° du produit
ABIN6730918
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6956480
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6974795
Quantité
96 tests
Fiche technique
Fiche technique
HSPG2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307245
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7396736
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7396733
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits HSPG2
: "Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia." dans: Biomedicines, Vol. 10, Issue 11, (2022) (PubMed).: "Expression and Circulating Levels of Perlecan in Breast Cancer - Implications for Oestrogen Dependent Stromal Remodeling." dans: Journal of mammary gland biology and neoplasia, Vol. 25, Issue 1, pp. 69-77, (2020) (PubMed).
: "Dynamic Assembly of Human Salivary Stem/Progenitor Microstructures Requires Coordinated α1β1 Integrin-Mediated Motility." dans: Frontiers in cell and developmental biology, Vol. 7, pp. 224, (2019) (PubMed).
: "Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation." dans: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, Vol. 17, Issue 2, pp. 451-461, (2016) (PubMed).
: "Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme." dans: European journal of pharmacology, Vol. 728, pp. 151-60, (2014) (PubMed).
: "Proteomics of Follicular Fluid from Women with Polycystic Ovary Syndrome Suggests Molecular Defects in Follicular Development." dans: The Journal of clinical endocrinology and metabolism, pp. jc20142086, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à HSPG2
heparan sulfate proteoglycan 2 (HSPG2), heparan sulfate proteoglycan 2 (hspg2), perlecan (heparan sulfate proteoglycan 2) (Hspg2), heparan sulfate proteoglycan 2 (Hspg2), AI852380, HSPG, HSPG2, Pcn, per, Per, PLC, Plc, PRCAN, SJA, SJS, SJS1Protein level used designations for HSPG2
- basement membrane-specific heparan sulfate proteoglycan core protein
- endorepellin (domain V region)
- perlecan proteoglycan
- heparan sulfate proteoglycan 2
- perlecan
- basement membrane-specific heparan sulfate proteoglycan core protein-like
- HSPG
- perlecan (heparan sulfate proteoglycan 2)
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