IDH2 Produits
(Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
Catégories
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008].
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Catégories IDH2 en vedette
IDH2 Anticorps
High quality antibodies with extensive validation data.
IDH2 Kits ELISA
Reliable ELISA kits for a wide range of species.
IDH2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
IDH2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (7)
N° du produit
ABIN7441520
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC, Neut
Validations
- (6)
N° du produit
ABIN7193379
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP, IF, ChIP
Validations
- (1)
- (5)
N° du produit
ABIN6142146
Quantité
100 μL
Fiche technique
Fiche technique
IDH2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6957224
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1138941
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1138942
Quantité
96 tests
Fiche technique
Fiche technique
IDH2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307372
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307371
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7409158
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits IDH2
: "IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer." dans: Molecular oncology, Vol. 12, Issue 5, pp. 602-610, (2019) (PubMed).: "Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ..." dans: Cancer discovery, Vol. 6, Issue 7, pp. 727-39, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." dans: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "Single muscle fiber proteomics reveals unexpected mitochondrial specialization." dans: EMBO reports, Vol. 16, Issue 3, pp. 387-95, (2015) (PubMed).
: "Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells." dans: The international journal of biochemistry & cell biology, Vol. 65, pp. 125-33, (2015) (PubMed).
: "Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms." dans: The British journal of dermatology, Vol. 170, Issue 3, pp. 687-93, (2014) (PubMed).
: "Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. ..." dans: Nature, Vol. 513, Issue 7516, pp. 110-4, (2014) (PubMed).
: "D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. ..." dans: Genes & development, Vol. 28, Issue 5, pp. 479-90, (2014) (PubMed).
: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." dans: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
: "Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value." dans: Blood, Vol. 116, Issue 12, pp. 2122-6, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à IDH2
isocitrate dehydrogenase subunit 2 (IDH2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2), isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2), isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S), isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2), isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867), D2HGA2, E430004F23, F6P23.14, F6P23_14, ICD-M, IDH, Idh-2, IDH-II, idh2, IDH2, IDHM, IDP, IDPM, IDPm, isocitrate dehydrogenase II, isocitrate dehydrogenase subunit 2, mNADP-IDH, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2, wu:fb33c06, wu:fk31e05, wu:fq43b01, zgc:55485Protein level used designations for IDH2
- NADP(+)-specific ICDH
- isocitrate dehydrogenase [NADP], mitochondrial
- oxalosuccinate decarboxylase
- ICD-M
- IDH
- IDP
- NADP+-specific isocitrate dehydrogenase
- NADPH-specific isocitrate dehydrogenase
- isocitrate dehydrogenase 2 (NADP+), mitochondrial
- isocitrate dehydrogenase [NADP], mitochondrial-like
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