IKZF1 Produits
(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
Catégories
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Catégories IKZF1 en vedette
IKZF1 Anticorps
High quality antibodies with extensive validation data.
IKZF1 Kits ELISA
Reliable ELISA kits for a wide range of species.
IKZF1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
IKZF1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN654180
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
N° du produit
ABIN7150361
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, ChIP
Validations
- (4)
N° du produit
ABIN3015622
Quantité
100 μL
Fiche technique
Fiche technique
IKZF1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967566
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1130242
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Validations
N° du produit
ABIN1130240
Quantité
96 tests
Fiche technique
Fiche technique
IKZF1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307650
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123400
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093023
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits IKZF1
: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." dans: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).: "Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia." dans: The Journal of biological chemistry, Vol. 291, Issue 8, pp. 4004-18, (2016) (PubMed).
: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." dans: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).
: "Transcriptional regulation of the Ikzf1 locus." dans: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).
: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." dans: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).
: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." dans: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).
: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." dans: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).
: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." dans: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).
: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." dans: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).
: "Ikaros: a key regulator of haematopoiesis." dans: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à IKZF1
IKAROS family zinc finger 1 (IKZF1), IKAROS family zinc finger 1 (Ikzf1), IKAROS family zinc finger 1 (Ikaros) (ikzf1), IKAROS family zinc finger 1 (ikzf1), 5832432G11Rik, hIk-1, hik-1, hlk-1, Hs.54452, hs.54452, IK1, ik1, IKAROS, ikaros, Ikaros, ikzf1, LyF-1, LYF1, lyf1, MGC108252, mKIAA4227, PRO0758, pro0758, RGD1562979, Zfpn1a1, ZNFN1A1, znfn1a1, Znfn1a1Protein level used designations for IKZF1
- CLL-associated antigen KW-6
- DNA-binding protein Ikaros
- Ikaros (zinc finger protein)
- ikaros family zinc finger protein 1
- lymphoid transcription factor LyF-1
- zinc finger protein, subfamily 1A, 1 (Ikaros)
- Ikaros transcription factor
- KAROS family zinc finger 1 (Ikaros)
- IKAROS family zinc finger 1 (Ikaros)
- DNA-binding protein Ikaros-like
- zinc finger protein subfamily 1A, 1
Vous êtes ici:
