IL12RB1 Produits
(Interleukin 12 Receptor beta 1 (IL12RB1))
Catégories
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Catégories IL12RB1 en vedette
IL12RB1 Anticorps
High quality antibodies with extensive validation data.
IL12RB1 Kits ELISA
Reliable ELISA kits for a wide range of species.
IL12RB1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
IL12RB1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (1)
- (1)
N° du produit
ABIN747863
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
IHC, IF
Validations
- (2)
N° du produit
ABIN7256826
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (2)
N° du produit
ABIN517100
Quantité
100 μL
Fiche technique
Fiche technique
IL12RB1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957018
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730742
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730741
Quantité
96 tests
Fiche technique
Fiche technique
IL12RB1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN7275013
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
N° du produit
ABIN6731329
Quantité
200 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1307680
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits IL12RB1
: "Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege." dans: PLoS ONE, Vol. 9, Issue 4, pp. e96120, (2014) (PubMed).: "Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency." dans: The Journal of allergy and clinical immunology, Vol. 131, Issue 4, pp. 1146-56, 1156.e1-5, (2013) (PubMed).
: "IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia." dans: Blood, Vol. 120, Issue 18, pp. 3774-82, (2012) (PubMed).
: "Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo." dans: Leukemia, Vol. 26, Issue 6, pp. 1365-74, (2012) (PubMed).
: "Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans." dans: Journal of dermatological science, Vol. 57, Issue 3, pp. 199-206, (2010) (PubMed).
: "Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription." dans: Cellular immunology, Vol. 241, Issue 1, pp. 7-13, (2006) (PubMed).
: "A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors." dans: Blood, Vol. 104, Issue 7, pp. 2095-101, (2004) (PubMed).
: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).
: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." dans: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, (1999) (PubMed).
: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).
Synonymes et noms alternatifs relatifs à IL12RB1
interleukin 12 receptor subunit beta 1 (Il12rb1), interleukin 12 receptor subunit beta 1 (IL12RB1), interleukin 12 receptor, beta 1 (Il12rb1), CD212, IL-12R, IL-12R-BETA1, IL-12R[b], Il12rb, IL12RB, IL12RB1Protein level used designations for IL12RB1
- interleukin-12 receptor subunit beta-1
- interleukin 12 receptor, beta 1
- IL12 receptor beta 1 subunit
- interleukin-12 receptor subunit beta-1-like
- IL-12 receptor beta component
- IL-12 receptor subunit beta-1
- IL-12R subunit beta-1
- interleukin-12 receptor beta-1 chain
- IL-12R-beta-1
- Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)
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