This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009].
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Andreassi, Zimmermann, Mitter, Fusco, De Vita, Devita, Saiardi, Riccio: "An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons." dans: Nature neuroscience, Vol. 13, Issue 3, pp. 291-301, (2010) (PubMed).
van Nieuwenhuijzen, Kashem, Matsumoto, Hunt, McGregor: "A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after ?-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination." dans: Neurochemistry international, Vol. 56, Issue 8, pp. 871-7, (2010) (PubMed).