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Influenza Nucleoprotein Produits

(Influenza Nucleoprotein (NP))
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).

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Catégories Influenza Nucleoprotein en vedette

Influenza Nucleoprotein Anticorps

High quality antibodies with extensive validation data.

Influenza Nucleoprotein Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Influenza Nucleoprotein recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Influenza A Virus H2N2
Application ELISA, WB, IF, IHC, IP, IC
Validations
  • (3)
  • (4)
N° du produit ABIN2452039
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Influenza A Virus H2N2
Application ELISA, WB, IHC, IC
Validations
  • (3)
  • (3)
N° du produit ABIN2452038
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Influenza B Virus
Application ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN5707182
Quantité 1 mL
Fiche technique Fiche technique

Influenza Nucleoprotein recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Influenza B Virus
Source HEK-293 Cells
Validations
N° du produit ABIN7385956
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Influenza A Virus
Source HEK-293 Cells
Validations
N° du produit ABIN7385954
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Influenza A Virus
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7519580
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits Influenza Nucleoprotein

Hao, Wang, Li: "FKBP5 Regulates RIG-I-Mediated NF-κB Activation and Influenza A Virus Infection." dans: Viruses, Vol. 12, Issue 6, (2020) (PubMed).

Hong, Song, Kim, Cho, Jeong, Yang, Jeong, Ahn, Jeong, Kim, Chang, Ko: "Morin Hydrate Inhibits Influenza Virus entry into Host Cells and Has Anti-inflammatory Effect in Influenza-infected Mice." dans: Immune network, Vol. 20, Issue 4, pp. e32, (2020) (PubMed).

Gogoi, Mansouri, Katikaneni, Jin: "New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice." dans: Frontiers in immunology, Vol. 11, pp. 1674, (2020) (PubMed).

Mansouri, Katikaneni, Gogoi, Pipkin, Machuca, Emtiazjoo, Jin: "Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state." dans: Mucosal immunology, Vol. 13, Issue 4, pp. 595-608, (2020) (PubMed).

Tan, Esterbauer, Vanderven, Juno, Kent, Wheatley: "Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice." dans: Frontiers in immunology, Vol. 10, pp. 611, (2020) (PubMed).

Zhao, Sridharan, Chen, Baker, Wang, Krug: "Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins." dans: Nature communications, Vol. 7, pp. 12754, (2018) (PubMed).

Kamal, Blanchfield, Belser, Music, Tzeng, Holiday, Burroughs, Sun, Maines, Levine, York: "Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies." dans: Journal of virology, Vol. 91, Issue 20, (2017) (PubMed).

Bose, McCaul, Mei, Sasman, He, Kramp, Shively, Yan, Henrickson: "Simulated Respiratory Secretion for Use in the Development of Influenza Diagnostic Assays." dans: PLoS ONE, Vol. 11, Issue 11, pp. e0166800, (2017) (PubMed).

Belardo, Cenciarelli, La Frazia, Rossignol, Santoro: "Synergistic effect of nitazoxanide with neuraminidase inhibitors against influenza A viruses in vitro." dans: Antimicrobial agents and chemotherapy, Vol. 59, Issue 2, pp. 1061-9, (2015) (PubMed).

Kim, Kim, Lee, Chu, Kang, Kim, Lee: "Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret." dans: Virology, Vol. 481, pp. 136-41, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à Influenza Nucleoprotein

nucleoprotein (NP)
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