Interferon, lambda 4 (Gene/pseudogene) Anticorps
(Interferon, lambda 4 (Gene/pseudogene) (IFNL4))
This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017].
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Catégories Interferon, lambda 4 (Gene/pseudogene) en vedette
Interferon, lambda 4 (Gene/pseudogene) Anticorps
High quality antibodies with extensive validation data.
Interferon, lambda 4 (Gene/pseudogene) recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
N° du produit
ABIN7156613
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA
Validations
N° du produit
ABIN7156616
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
Validations
N° du produit
ABIN7156615
Quantité
100 μg
Fiche technique
Fiche technique
Synonymes et noms alternatifs relatifs à Interferon, lambda 4 (Gene/pseudogene)
interferon lambda 4 (gene/pseudogene) (IFNL4), IFN-lambda-4, IFNANProtein level used designations for Interferon, lambda 4 (Gene/pseudogene)
- IFN-lambda-4
- interferon lambda-4
- interferon, lambda 4
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