(1 reference)-
- Application
- Inhibition (Inh)
- Fonction
- Hsp90 inhibitor
- Attributs du produit
- Hsp90 inhibitor.
- Purification
- Produced by fermentation
- Pureté
- 97 % by TLC
- Formula
- C18H17CIO6
- Solubility
- Soluble in DMSO
-
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
ResveratrolAct 501-36-0 3,4',5-Trihydroxy-trans-stilbene
PanobinostatInh 404950-80-7 (E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
HPA (Hexyl-4-pentynoic acid)Inh Cell-permeable 96017-59-3 2-(2-Propynyl)octanoic acid (racemic)
EX-527Inh Cell-permeable 49843-98-3 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)
DaminozideInh 1596-84-5 1-(2,2-Dimethylhydrazide)butanedioic acid
Mithramycin AInh 18378-89-7
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- Commentaires
-
Source: Produced by fermentation.
Appearance: White to Yellow Solid - Restrictions
- For Research Use only
-
- Format
- Solid
- Précaution d'utilisation
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- Conseil sur la manipulation
- Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- Stock
- -20 °C
-
-
: "TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation." dans: Anti-cancer drugs, Vol. 21, Issue 5, pp. 543-52, (2010) (PubMed).
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: "TLN-4601, a novel anticancer agent, inhibits Ras signaling post Ras prenylation and before MEK activation." dans: Anti-cancer drugs, Vol. 21, Issue 5, pp. 543-52, (2010) (PubMed).
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- Sujet
- Radicicol inhibits src (IC50=0.27myM) and src-like kinases, leading to hypophosphorylation of retinoblastoma tumor suppressor protein. It causes morphological reversion of ras-transformed cells and leads to selective depletion of Raf kinase. It also displays anti-angiogenic activity, and binds to and inhibits Hsp 90 molecular chaperone. It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.
- Poids moléculaire
- 364.8
- Numéro CAS
- 12772-57-5
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