CAL-101 (Idelalisib, GS-1101)
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- Application
- Inhibition Assay (InhA), Functional Studies (Func)
- Fonction
- CAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM, shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
- Attributs du produit
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Target: PI3K inhibitor, mTOR inhibitor
Receptor: PI3Kα/β/δ/γ, mTOR - Purification
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- Pureté
- 98 %
- Formula
- C22H18FN7O
- Solubility
- DMSO ≥80mg/mL
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Solid
- Stock
- -20 °C
- Stockage commentaire
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - Date de péremption
- 24 months
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- Sujet
- PI3K/Akt/mTOR Signaling
- Poids moléculaire
- 415.42 g/mol
- Numéro CAS
- 870281-82-6
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