Dacomitinib (PF299804, PF299)
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- Application
- Inhibition Assay (InhA), Functional Studies (Func)
- Fonction
- Dacomitinib(PF299804, PF-00299804) is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.
- Attributs du produit
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Target: EGFR inhibitor, HER2 inhibitor
Receptor: EGFR/ErbB2/ErbB4 - Purification
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- Pureté
- 97 % +
- Formula
- C24H25ClFN5O2
- Solubility
- DMSO > 10 mM
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Solid
- Stock
- -20 °C
- Stockage commentaire
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - Date de péremption
- 24 months
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- Sujet
- JAK/STAT Signaling,Tyrosine Kinase/Adaptors
- Poids moléculaire
- 469.94 g/mol
- Numéro CAS
- 1110813-31-4
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