AEE788
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- Application
- Inhibition Assay (InhA), Functional Studies (Func)
- Fonction
- AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1. Phase 1/2.
- Attributs du produit
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Target: EGFR inhibitor, Bcr-Abl inhibitor, Src inhibitor, HER2 inhibitor
Receptor: EGFR/c-Abl/FLT1/c-Src, HER2/ErbB2, HER4/ErbB4 - Purification
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- Pureté
- 98 %
- Formula
- C27H32N6
- Solubility
- 100 mM in DMSO
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Solid
- Stock
- -20 °C
- Stockage commentaire
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - Date de péremption
- 24 months
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- Sujet
- Tyrosine Kinase/Adaptors
- Poids moléculaire
- 440.58 g/mol
- Numéro CAS
- 497839-62-0
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