Dacogen
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- Application
- Inhibition Assay (InhA), Functional Studies (Func)
- Fonction
- Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate.
- Attributs du produit
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Tradename: DAUNOXOME
Source of Compound: Streptomyces peucetius, FI-6339, NDC-0082-4155, RP-13057
Target: DNA Methyltransferase inhibitor
Receptor: DNA Methyltransferase
- Purification
- All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.
- Pureté
- 99.50 %
- Formula
- C8H12N4O4
- Solubility
- DMSO 45 mg/mL,Water 10 mg/mL
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Solid
- Stock
- -20 °C
- Stockage commentaire
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For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours. - Date de péremption
- 24 months
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- Sujet
- Chromatin/Epigenetic
- Poids moléculaire
- 228.21 g/mol
- Numéro CAS
- 2353-33-5
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