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5-Azacytidine

Name: 5-Azacytidine
Brand: antibodies-online
SKU: ABIN7233228
Price: 75.38 EUR
Availability: InStock

Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

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N° du produit ABIN7233228

Fiche de données

Application

Inhibition (Inh)

Fonction

DNA hypomethylation agent

Attributs du produit

Specific inhibitor of DNA methyltransferase. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human mesenchymal stem cells by activating ERK. Induces apoptosis in multiple myeloma cells via ATR-mediated DNA double strand breaks. Cell permeable.

Pureté

>98 %

Chemical Name

4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

Formula

C8H12N4O5

Perméabilité

Cell-permeable

Solubility

Soluble in DMSO (up to 25 mg/ml), or in Water (up to 12 mg/ml).
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Radicicol
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Restrictions

For Research Use only
Format

Powder

Précaution d'utilisation

GHS – Classification
Acute toxicity, Oral (Category 4), H302
Germ cell mutagenicity (Category 2), H341
Carcinogenicity (Category 1A), H350
Reproductive toxicity (Category 1B), H360
Specific target organ toxicity - repeated exposure (Category 1), H372
Long-term (chronic) aquatic hazard (Category 1), H410

Stock

-20 °C
Sujet

Ladakamycin, U-18496, NSC-102816, AzaC,Epigenetics,Chromatin,DNA methyltransferase,Stem cells,Cell death,Infectious disease,Apoptosis inducer,DNA damage

Poids moléculaire

244.2

Numéro CAS

320-67-2