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GSK2879552

Inh 1401966-69-5 4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
N° du produit ABIN7233256
  • Application
    Inhibition (Inh)
    Fonction
    Lysine Demethylase inhibitor
    Attributs du produit
    GSK289552 is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 μM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.
    Pureté
    >98 %
    Chemical Name
    4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
    Formula
    C23H28N2O2 •2HCl
    Solubility
    Soluble in DMSO (up to 25 mg/ml) and in Water (up to at least 25 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    -20 °C
  • Sujet
    Epigenetics,Proliferation,Protein demethylase,Cancer,Posttranslational modification,Chromatin
    Poids moléculaire
    437.40
    Numéro CAS
    1401966-69-5
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