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MS-275

Inh 209783-80-2
N° du produit ABIN7233270
  • Application
    Inhibition (Inh)
    Fonction
    HDAC inhibitor
    Attributs du produit
    Potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 > 100 μM). In vivo, MS-275 has been shown to inhibit tumor growth via induction of the tumor supressors p21WAF1/CIP1 and gelsolin and to block cell proliferation in a variety of cancer cell lines. The compound has also shown significant anti-rheumatic activity in rat and mouse arthritis models.
    Pureté
    >98 %
    Formula
    C21H20N4O3
    Solubility
    Soluble in DMSO (up to 25 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    -20 °C
  • Sujet
    Entinostat,Epigenetics,Proliferation,Protein deacetylase,Inflammation,Cancer,Posttranslational modification,Chromatin
    Poids moléculaire
    376.42
    Numéro CAS
    209783-80-2
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