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PBIT

Inh 2514-30-9 2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one

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N° du produit ABIN7233273

Fiche de données

Application

Inhibition (Inh)

Fonction

JARID1 inhibitor

Attributs du produit

The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.

Pureté

>98 %

Chemical Name

2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one

Formula

C14H11NOS

Solubility

Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
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Restrictions

For Research Use only
Format

Powder

Précaution d'utilisation

GHS – Classification
Not a hazardous substance or mixture

Stock

-20 °C
Sujet

Epigenetics,Proliferation,Protein demethylase,Vesicles,Cancer,Posttranslational modification,Chromatin

Poids moléculaire

241.31

Numéro CAS

2514-30-9