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Remodelin

Name: Remodelin
Brand: antibodies-online
SKU: ABIN7233278
Price: 123.85 EUR
Availability: InStock

Inh 949912-58-7 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

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N° du produit ABIN7233278

Fiche de données

Application

Inhibition (Inh)

Fonction

Acetyl-transferase NAT10 inhibitor

Attributs du produit

Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.

Pureté

>98 %

Chemical Name

4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile

Formula

C15H14N4S

Solubility

Soluble in DMSO (up to 40 mg/ml)
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Radicicol
Inh 12772-57-5

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HPA (Hexyl-4-pentynoic acid)
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EX-527
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Daminozide
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Restrictions

For Research Use only
Format

Powder

Stock

-20 °C
Sujet

Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin

Poids moléculaire

282.36

Numéro CAS

949912-58-7