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Remodelin

Inh 949912-58-7 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
N° du produit ABIN7233278
  • Application
    Inhibition (Inh)
    Fonction
    Acetyl-transferase NAT10 inhibitor
    Attributs du produit
    Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.
    Pureté
    >98 %
    Chemical Name
    4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
    Formula
    C15H14N4S
    Solubility
    Soluble in DMSO (up to 40 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    -20 °C
  • Sujet
    Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin
    Poids moléculaire
    282.36
    Numéro CAS
    949912-58-7
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