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Splitomicin

Inh 5690-03-9 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
N° du produit ABIN7233294
  • Application
    Inhibition (Inh)
    Fonction
    SIRT1 inhibitor
    Attributs du produit
    Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome. Reverses ischemic preconditioning-induced cardioprotection in a mouse model.
    Pureté
    >98 %
    Chemical Name
    1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
    Formula
    C13H10O2
    Solubility
    Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    RT
  • Sujet
    Splitomycin,Epigenetics,Protein deacetylase,Ischemia,Heart disease,Posttranslational modification,Chromatin
    Poids moléculaire
    198.22
    Numéro CAS
    5690-03-9
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