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SRT1720 HCl

Act 1001645-58-4 N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride
N° du produit ABIN7233295
  • Application
    Activation (Act)
    Fonction
    SIRT1 activator
    Attributs du produit
    Sirtuin1 (SIRT1) activator, EC1.5 = 0.16 μM, that reduces glucose levels and hyperinsulinemia in mouse and rat models of obesity. SRT1720 represses expression of circadian clock genes in vitro and in vivo. It inhibits vascular inflammation caused by angiotensin II-induced atherosclerosis and reverses abnormal mitochondrial function in primary neurons exposed to 20-HETE. Ameliorates hypoxic injury in pancreatic β-cells, and enhances ferroptosis in head and neck cancer cells.
    Pureté
    >98 %
    Chemical Name
    N-[2-[3-(Piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide, hydrochloride
    Formula
    C25H23N7OS•HCl
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    -20 °C
  • Sujet
    SIRT 1933,Redox,Epigenetics,Apoptosis inhibitor,Mitochondrial function,Protein deacetylase,Oxidative stress,Cell death,Circadian rhythm,Diabetes,Kidney disease,Atherosclerosis,Inflammation,Posttranslational modification,Obesity,Chromatin
    Poids moléculaire
    506.0
    Numéro CAS
    1001645-58-4
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