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UNC-0379

Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
N° du produit ABIN7233304
  • Application
    Inhibition (Inh)
    Fonction
    SETD8 inhibitor
    Attributs du produit
    UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases. IC50's = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.
    Pureté
    >98 %
    Chemical Name
    6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
    Formula
    C23H35N5O2
    Solubility
    Soluble in DMSO (up to 30 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Stock
    -20 °C
  • Sujet
    Proliferation,Epigenetics,p53,Protein methyltransferase,Neuroscience,Cancer,Posttranslational modification,Chromatin
    Poids moléculaire
    413.56
    Numéro CAS
    1620401-82-2
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