JAK1 Produits
(Janus Kinase 1 (JAK1))
Catégories
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008].
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Catégories JAK1 en vedette
JAK1 Anticorps
High quality antibodies with extensive validation data.
JAK1 Kits ELISA
Reliable ELISA kits for a wide range of species.
JAK1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
JAK1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (4)
- (12)
N° du produit
ABIN6255762
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN7205612
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (4)
N° du produit
ABIN7268038
Quantité
100 μL
Fiche technique
Fiche technique
JAK1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
N° du produit
ABIN1981723
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968075
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6962689
Quantité
96 tests
Fiche technique
Fiche technique
JAK1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1308275
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5508974
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7413241
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits JAK1
: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." dans: eLife, Vol. 10, (2021) (PubMed).: "Selective Janus Kinase 1 Inhibition Is a Promising Therapeutic Approach for Lupus Erythematosus Skin Lesions." dans: Frontiers in immunology, Vol. 11, pp. 344, (2021) (PubMed).
: "In vivo and in vitro effects of microRNA-221 on hepatocellular carcinoma development and progression through the JAK-STAT3 signaling pathway by targeting SOCS3." dans: Journal of cellular physiology, Vol. 234, Issue 4, pp. 3500-3514, (2019) (PubMed).
: "Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway." dans: Oncology reports, Vol. 39, Issue 3, pp. 1081-1089, (2018) (PubMed).
: "A novel fluorinated triazole derivative suppresses macrophage activation and alleviates experimental colitis via a Twist1-dependent pathway." dans: Biochemical pharmacology, Vol. 155, pp. 275-287, (2018) (PubMed).
: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." dans: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).
: "Lutein modulates transcription dysregulation of adhesion molecules and spermatogenesis transcription factors induced by testicular ischemia reperfusion injury: it could be SAFE." dans: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 389, Issue 5, pp. 539-51, (2017) (PubMed).
: "BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo." dans: Molecular carcinogenesis, Vol. 56, Issue 3, pp. 1137-1149, (2017) (PubMed).
: "Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 97, Issue 9, pp. 1008-1019, (2017) (PubMed).
: "Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition." dans: Scientific reports, Vol. 7, Issue 1, pp. 7958, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à JAK1
Janus kinase 1 (JAK1), Janus kinase 1 (Jak1), Janus kinase 1 (jak1), tyrosine-protein kinase JAK1 (LOC100286690), AA960307, C130039L05Rik, jak1, JAK1A, JAK1B, JTK3, wu:fb93e10Protein level used designations for JAK1
- tyrosine-protein kinase JAK1
- JAK-1
- etID309794.6
- fb93e10
- jak-1
- jak1 kinase
- Janus protein tyrosine kinase 1
- Janus kinase 1 (a protein tyrosine kinase)
- tyrosine kinase JAK1
- protein tyrosine kinase
- Janus kinase 1
- Tyrosine-protein kinase Jak1
- tyrosine-protein kinase JAK1-like
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