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JMY Produits

(Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.

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Catégories JMY en vedette

JMY Anticorps

High quality antibodies with extensive validation data.

JMY Kits ELISA

Reliable ELISA kits for a wide range of species.

JMY Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

JMY recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (4)
N° du produit ABIN530707
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF
Validations
  • (3)
N° du produit ABIN530706
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7157162
Quantité 100 μg
Fiche technique Fiche technique

JMY recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN5648309
Quantité 96 tests
Fiche technique Fiche technique

JMY recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123654
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1308311
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3093298
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits JMY

Coutts, Weston, La Thangue: "A transcription co-factor integrates cell adhesion and motility with the p53 response." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 19872-7, (2009) (PubMed).

Zuchero, Coutts, Quinlan, Thangue, Mullins: "p53-cofactor JMY is a multifunctional actin nucleation factor." dans: Nature cell biology, Vol. 11, Issue 4, pp. 451-9, (2009) (PubMed).

Nordgard, Johansen, Alnaes, Bucher, Syvänen, Naume, Børresen-Dale, Kristensen: "Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients." dans: Genes, chromosomes & cancer, Vol. 47, Issue 8, pp. 680-96, (2008) (PubMed).

Coutts, Boulahbel, Graham, La Thangue: "Mdm2 targets the p53 transcription cofactor JMY for degradation." dans: EMBO reports, Vol. 8, Issue 1, pp. 84-90, (2007) (PubMed).

Shikama, Lee, France, Delavaine, Lyon, Krstic-Demonacos, La Thangue: "A novel cofactor for p300 that regulates the p53 response." dans: Molecular cell, Vol. 4, Issue 3, pp. 365-76, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à JMY

junction mediating and regulatory protein, p53 cofactor (JMY), junction mediating and regulatory protein, p53 cofactor (jmy), junction-mediating and regulatory protein (Jmy), WHDC1L3

Protein level used designations for JMY

  • junction mediating and regulatory protein, p53 cofactor
  • junction-mediating and regulatory protein
  • junction-mediating and -regulatory protein
  • WAS protein homology region 2 domain containing 1-like 3
  • p300 transcriptional cofactor JMY
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