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KDM2A Produits

(Lysine (K)-Specific Demethylase 2A (KDM2A))

Catégories

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

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Catégories KDM2A en vedette

KDM2A Anticorps

High quality antibodies with extensive validation data.

KDM2A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

KDM2A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
N° du produit ABIN387896
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA
Validations
  • (3)
N° du produit ABIN7193407
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7244933
Quantité 200 μL
Fiche technique Fiche technique

KDM2A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6228355
Quantité 96 tests
Fiche technique Fiche technique

KDM2A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123806
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353718
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3093402
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits KDM2A

Ou, Zhu, Zhao, Li, Tao, Lu, He, Li, Ren, Xu: "HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway." dans: Journal of cellular physiology, (2018) (PubMed).

Dhar, Alam, Li, Wagner, Chung, Ahn, Lee: "Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells." dans: The Journal of biological chemistry, Vol. 289, Issue 11, pp. 7483-96, (2014) (PubMed).

Wagner, Alam, Dhar, Giri, Li, Wei, Giri, Cascone, Kim, Ye, Multani, Chan, Erez, Saigal, Chung, Lin, Wu, Hung, Heymach, Lee: "KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling." dans: The Journal of clinical investigation, Vol. 123, Issue 12, pp. 5231-46, (2013) (PubMed).

Tsukada, Fang, Erdjument-Bromage, Warren, Borchers, Tempst, Zhang: "Histone demethylation by a family of JmjC domain-containing proteins." dans: Nature, Vol. 439, Issue 7078, pp. 811-6, (2006) (PubMed).

Andersen, Lam, Leung, Ong, Lyon, Lamond, Mann: "Nucleolar proteome dynamics." dans: Nature, Vol. 433, Issue 7021, pp. 77-83, (2005) (PubMed).

Nagase, Ishikawa, Suyama, Kikuno, Hirosawa, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." dans: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 1, pp. 63-70, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à KDM2A

lysine demethylase 2A (KDM2A), lysine (K)-specific demethylase 2A (Kdm2a), lysine demethylase 2A (Kdm2a), lysine (K)-specific demethylase 2Aa (kdm2aa), 5530401A10Rik, 100043628, AA589516, AW536790, Cxxc8, CXXC8, fb76b11, Fbl7, FBL7, Fbl11, FBL11, FBXL11, Fbxl11, Gm4560, Jhdm1, JHDM1A, Jhdm1a, KDM2A, lalina, LILINA, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606

Protein level used designations for KDM2A

  • F-box and leucine-rich repeat protein 11
  • jumonji C domain-containing histone demethylase 1A
  • lysine-specific demethylase 2A
  • F-box protein containing leucine repeats
  • F-box/LRR-repeat protein 11
  • [Histone-H3]-lysine-36 demethylase 1A
  • jmjC domain-containing histone demethylation protein 1A
  • lysine (K)-specific demethylase 2A
  • CXXC-type zinc finger protein 8
  • JmjC domain-containing histone demethylation protein 1B
  • lysine (K)-specific demethylase 2B
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