KIR2DS3 Produits
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 (KIR2DS3))
Catégories
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
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Catégories KIR2DS3 en vedette
KIR2DS3 Anticorps
High quality antibodies with extensive validation data.
KIR2DS3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
KIR2DS3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN651950
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
N° du produit
ABIN7157515
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
N° du produit
ABIN517338
Quantité
100 μg
Fiche technique
Fiche technique
KIR2DS3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2724259
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits KIR2DS3
: "Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule." dans: Genes and immunity, Vol. 10, Issue 2, pp. 162-73, (2009) (PubMed).Synonymes et noms alternatifs relatifs à KIR2DS3
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3), NKAT7Protein level used designations for KIR2DS3
- MHC class I NK cell receptor
- NKAT-7
- killer cell immunoglobulin-like receptor 2DS3
- natural killer cell inhibitory receptor
- natural killer-associated transcript 7
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