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SensoLyte® 520 Neprilysin Activity Assay Kit

Act, FRET Fluorometric
N° du produit ABIN1882538
  • Antigène Voir toutes MME Kits
    MME (Membrane Metallo-Endopeptidase (MME))
    Méthode de détection
    Fluorometric
    Application
    Activation (Act), Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Marque
    SensoLyte®
    Attributs du produit
    The SensoLyte® 520 Neprilysin Assay Kit employs a novel internally quenched 5-FAM/QXL™ FRET substrate for the detection of neprilysin activity. The enzyme cleaves the FRET substrate into two separate fragments resulting in the release of 5-FAM fluorescence, which can be monitored at excitation /emission= 490/520 nm. The long wavelength fluorescence of 5-FAM is less interfered by the autofluorescence of components in biological samples and test compounds. The assay can detect as low as 0.78 ng/mL of active neprilysin.
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  • Commentaires

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Protect Components A abd B from light and moisture.
    Stock
    -80 °C
    Stockage commentaire
    Store all kit Components at -20 °C, except Component C, which should be stored at -80 °C.
  • Antigène
    MME (Membrane Metallo-Endopeptidase (MME))
    Autre désignation
    Neprilysin (MME Produits)
    Classe de substances
    Chemical
    Sujet
    Neprilysin (NEP) is a transmembrane metallopeptidase normally expressed by a variety of tissues. It is also known as neutral endopeptidase, and enkephalinase. NEP cleaves peptides at the N-terminal side of hydrophobic amino acid residues and is responsible for the degradation and inactivation of a variety of physiological substrates. NEP is a major extracellular amyloid beta-peptide degrading enzyme in the brain and targeting NEP is considered a potential therapeutic strategy for the prevention and treatment of Alzheimer's disease. NEP has also been implicated in the pathogenesis of hypertension, diabetes, and cancer.
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