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Thymic Stromal Lymphopoietin Kit ELISA

TSLP Reactivité: Souris Colorimetric Sandwich ELISA 0.02-1.0 ng/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (citrate), Plasma (heparin), Serum
N° du produit ABIN4987142
  • Antigène Voir toutes Thymic Stromal Lymphopoietin (TSLP) Kits ELISA
    Thymic Stromal Lymphopoietin (TSLP)
    Reactivité
    • 13
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    0.02-1.0 ng/mL
    Seuil minimal de détection
    0.02 ng/mL
    Application
    ELISA
    Type d'échantillon
    Cell Culture Supernatant, Serum, Plasma (heparin), Plasma (citrate), Plasma (EDTA)
    Analytical Method
    Quantitative
    Specificité
    Natural and recombinant Mouse TSLP Ligand
    Sensibilité
    7 pg/mL
    Matériel non inclus
    • Microplate reader.
    • Pipettes and pipette tips.
    • EP tube Deionized or distilled water.
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  • Indications d'application
    Detection Wavelength: 450 nm
    Volume d'échantillon
    20 μL
    Durée du test
    3 h
    Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C
  • Antigène Voir toutes Thymic Stromal Lymphopoietin (TSLP) Kits ELISA
    Thymic Stromal Lymphopoietin (TSLP)
    Autre désignation
    TSLP (TSLP Produits)
    Sujet
    Thymic Stromal Lymphopoietin (TSLP) is a member of the B cell-stimulating factor family. Originally identified from the conditioned medium of a mouse thymic stromal cell line that promoted B-cell development, TSLP is expressed in thymus, spleen, kidney, lung, and bone marrow. Mouse TSLP cDNA encodes a 140 amino acid (aa) residue precursor protein with a 19 aa signal sequence. TSLP activity overlaps with that of IL-7, playing a key role in the development of B cells, as well as stimulating the growth of thymocytes and T cells. TSLP stimulates monocytes to produce T cell-attracting chemokines such as TARC (CCL17) and MDC (CCL22). TSLP also activates dendritic cell-primed CD4 T cells to produce Th2 cytokines, including IL-4, IL-5, IL-13, and TNFα. This hematopoietic cytokine binds to a heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Binding induces activation of STAT3 and STAT5 via phosphorylation. Mouse TSLP shares approximately 43 % amino acid sequence identity with human TSLP.
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