FGF1 Kit ELISA

N° du produit ABIN5510538

Détail du produit FGF1 Kit ELISA

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Épitope: AA 2-155

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human FGF1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: E.coli
Immunogen sequence: A2-D155

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: FGF1 (Fibroblast Growth Factor 1 (Acidic) (FGF1))

Autre désignation: FGF1 (FGF1 Produits)

Synonymes: AFGF Kit ELISA, ECGF Kit ELISA, ECGF-beta Kit ELISA, ECGFA Kit ELISA, ECGFB Kit ELISA, FGF-1 Kit ELISA, FGF-alpha Kit ELISA, FGFA Kit ELISA, GLIO703 Kit ELISA, HBGF-1 Kit ELISA, HBGF1 Kit ELISA, Fgf1 Kit ELISA, FGF1 Kit ELISA, aFGF Kit ELISA, ecgf Kit ELISA, fgfa Kit ELISA, ecgfa Kit ELISA, ecgfb Kit ELISA, fgf-1 Kit ELISA, hbgf1 Kit ELISA, glio703 Kit ELISA, ecgf-beta Kit ELISA, fgf-alpha Kit ELISA, Dffrx Kit ELISA, Fam Kit ELISA, Fgf-1 Kit ELISA, Fgfa Kit ELISA, zgc:136885 Kit ELISA, LOC100221393 Kit ELISA, fgf1 Kit ELISA, zgc:73249 Kit ELISA, fibroblast growth factor 1 Kit ELISA, fibroblast growth factor 1 L homeolog Kit ELISA, fibroblast growth factor 1b Kit ELISA, fibroblast growth factor 1a Kit ELISA, FGF1 Kit ELISA, fgf1.L Kit ELISA, fgf1 Kit ELISA, Fgf1 Kit ELISA, fgf1b Kit ELISA, LOC100221393 Kit ELISA, fgf1a Kit ELISA

Sujet:

Protein Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. .

Background: Heparin-binding growth factor 1 is a protein that in humans is encoded by the FGF1 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. The FGF1 gene was mapped to chromosome 5q31.3-q33.2 by in situ hybridization.

Synonyms: Fibroblast growth factor 1,FGF-1,Acidic fibroblast growth factor,aFGF,Endothelial cell growth factor,ECGF,Heparin-binding growth factor 1,HBGF-1,FGF1,FGFA,

Full Gene Name: Fibroblast growth factor 1

Cellular Localisation: Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59..

UniProt: P05230

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway