TGFA Kit ELISA

N° du produit ABIN5510561

Détail du produit TGFA Kit ELISA

Antigène: TGFA (Transforming Growth Factor, alpha (TGFA))

Épitope: AA 40-89

Reactivité: Cheval

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of horse equine TGF alpha

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: E.coli,V40-A89

Réactivité croisée (Details): There is cross-reactivity with TGF beta 2, TGF beta 3, TGF beta 5<1 % .

Attributs du produit:

Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: TGFA (Transforming Growth Factor, alpha (TGFA))

Autre désignation: TGFA (TGFA Produits)

Synonymes: TFGA Kit ELISA, LOC100009482 Kit ELISA, TGF alpha Kit ELISA, TGFA Kit ELISA, wa-1 Kit ELISA, wa1 Kit ELISA, RATTGFAA Kit ELISA, TGFAA Kit ELISA, NV15606 Kit ELISA, si:ch211-10e8.7 Kit ELISA, transforming growth factor alpha Kit ELISA, transforming growth factor alpha L homeolog Kit ELISA, transforming growth factor-alpha Kit ELISA, transforming growth factor, alpha Kit ELISA, TGFA Kit ELISA, TGF-A Kit ELISA, Tgfa Kit ELISA, tgfa.L Kit ELISA, LOC100121300 Kit ELISA, LOC100009150 Kit ELISA, tgfa Kit ELISA

Sujet:

Protein Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Background: Transforming growth factor alpha(TGF-alpha) is upregulated in some horse equine cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects. TGFalpha stimulates neural cell proliferation in the adult injured brain. Transforming growth factor alpha gene(TGFA) maps to horse equine chromosome 2 close to the breakpoint of the t(2,8) variant translocation in Burkitt lymphoma. Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells, the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic horse equine TGF-alpha showed similar immunoreactivity when compared with horse equine TGF-alpha. Thus, the 50-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines.

Synonyms: Protransforming growth factor alpha,Transforming growth factor alpha,TGF-alpha,EGF-like TGF,ETGF,TGF type 1,TGFA,

Full Gene Name: Protransforming growth factor alpha

Cellular Localisation: Transforming growth factor alpha: Secreted, extracellular space.

UniProt: P01135

Pathways: Signalisation NF-kappaB, Signalisation RTK, EGFR Signaling Pathway